肥胖2型糖尿病患者血清MCP-1水平变化及其与AS的关系研究

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摘要目的探讨肥胖2型糖尿病（T2DM）患者血清单核细胞趋化因子1（MCP-1）的水平变化及其与动脉粥样硬化（AS）的关系。方法选取2015年1月～2016年8月在我院内分泌科就诊的新诊断的肥胖的T2DM患者（T2DM肥胖组，BMI≥28.0 kg/m2）30例，体型适中的T2DM患者（T2DM非肥胖组，18.5 kg/m2≤BMI＜24.0 kg/m2）30例，及正常体检者（NC组，18.5 kg/m2≤BMI＜24.0 kg/m2）30例，检测各组受检者空腹血清MCP-1水平及其他实验室指标，并计算胰岛素抵抗指数（HOMA-IR）、胰岛素敏感性指数（ISI）及血浆致动脉粥样硬化指数（AIP）。结果①T2DM肥胖组、T2DM非肥胖组血清MCP-1水平明显高于NC组，T2DM肥胖组血清MCP-1水平高于T2DM非肥胖组，差异有统计学意义（P＜0.05）。②相关性分析显示，血清MCP-1与体质指数（BMI）、三酰甘油（TG）、总胆固醇（TC）、空腹血糖（FPG）、HOMA-IR、AIP成正相关（P＜0.05），与HDL-C、ISI成负相关（P＜0.05）。③多元逐步回归分析以MCP-1为因变量的多元逐步回归分析示BMI、TC、FPG、AIP均进入回归方程（P＜0.05）。结论MCP-1是促进AS及IR发生、发展的关键因素之一，通过检测其水平变化及实施相应干预，可减轻患者IR及AS程度，有望为T2DM大血管及微血管并发症的治疗提供全新的切入靶点。

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	王慧慧
	闫晓光
	于修楠
	张海军
	孙哲

关键词 ：单核细胞趋化因子1, 肥胖, 2型糖尿病, 胰岛素抵抗, 动脉粥样硬化

Abstract：ObjectiveTo explore change of serum monocyte chemoattractant protein-1 (MCP-1)level in obese patients with type 2 diabetes mellitus(T2DM)and its relationship with atherosclerosis(AS).MethodsFrom January 2015 to August 2016,30 patients newly diagnosed as T2DM in obesity(T2DM obesity group,BMI≥28.0 kg/m2),30 patients in moderate size(T2DM non-obesity group,18.5 kg/m2≤BMI＜24.0 kg/m2),and 30 healthy participants after physical examinations (NC group,18.5 kg/m2≤BMI＜24.0 kg/m2).The levels of serum MCP-1 and other experimental indexes in empty stomach in each group were tested.Homeostasis model assessment of insulin resistance(HOMA-IR),insulin sensitivity index(ISI), and atherogenic index of plasma(AIP)were calculated.ResultsThe①levels of serum MCP-1 in the T2DM obesity group and T2DM non-obesity group were both much higher than that in the NC group.Serum MCP-1 in the T2DM obesity group was high than that in the T2DM non-obesity group with a statistical difference(P＜0.05).②Correlation analysis indicated that serum MCP-1 had positive relationships with body mass index(BMI),triglyceride(TG),total cholesterol(TC), fasting plasma glucose(FPG),HOMA-IR and AIP(P＜0.05).Serum MCP-1 was in a negative relationship with high-density lipoprotein cholesterol(HDL-C)or ISI(P＜0.05).③With regard to multiple stepwise regression analysis,it was indicated BMI,TC,FPG,and AIP were all enrolled into the regression equation based on the dependent variable of MCP-1 (P＜0.05).ConclusionMCP-1 is one of the key factors to promote occurrence and development of AS and IR.By testing the level of MCP-1 and implementing the corresponding intervention,it can relieve the degree of IR and AS.It is expected that MCP-1 will become a new cutting target for the treatment of macrovascular and microvascular complications in T2DM.

Key words： Monocyte chemoattractant protein-1 Obesity Type 2 diabetes mellitus Insulin resistance Atherosclerosis

基金资助:黑龙江省齐齐哈尔市科学技术计划项目（SFZD-2015143）

引用本文:

王慧慧;闫晓光;于修楠;张海军;孙哲. 肥胖2型糖尿病患者血清MCP-1水平变化及其与AS的关系研究[J]. 中国当代医药, 2017, 24(2): 39-41.
WANG Hui-hui;YAN Xiao-guang;YU Xiu-nan;ZHANG Hai-jun;SUN Zhe. Research on change of serum MCP-1 level in obese patients with type 2 diabetes and its relationship with AS. 中国当代医药, 2017, 24(2): 39-41.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2017/V24/I2/39

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