Esearch progress of dexmedetomidine on preventing shivering during intraspinal anesthesia
LUO Shuang-shuang1 YAN Jue-ji2▲ CHEN Can2
1.Medical Colleges Of Guilin,Guilin 541004,China;
2.Department of Anesthesiology,Red Cross Hospital of Wuzhou City in the Guangxi Zhuang Autonomous Region,Wuzhou 543000,China
Abstract：Thermostasis is a critical factor to ensure the normal physiological function of human body.Shivering is a common complication which can be induced by versatility reasons during anesthesia.Shivering is a stress reaction in which the temperature regulating center orders the skeletal muscles to contract fast to increase body temperature,especially under intraspinal anesthesia.As a new selective α2-adrenergic receptor agonist.Dexmedetomidine with the sedation and analgesia effect,has high effectiveness on preventing shivering and optimizing the quality of intraspinal anesthesia.This paper reviews to investigate the effect of dexmedetomidine on preventing shivering during intraspinal anesthesia.
De Witte J，Sessler DI.Perioperativeshiverillg：physiology and pharmacyology[J].Anesthesiology，2002，96（2）：467-484.
[2]
Fairbanks CA，Stone LS，Wilcox GL.Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis[J]. Pharmacol Ther，2009，123（2）：224-238.
[3]
Nelson LE，Lu J，Guo TZ，et al.The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects[J]. Anesthesiology，2003，98（2）：428-436.
Doufas AG，Lin CM，Suleman MI，et al.Dexmedetermidine and memperidine additively reduce the shivering threshold in humans[J].Stroke，2003，34（5）：1218-1223．
[19]
Bajwa SJ，Gupta S，Kaur J，et al.Reduction in the incidence of shivering with perioprative dexmedetomidine：a randomized prospective study[J].J Anesthesiol Clin Pharmacol，2012，28（1）：86-91.
[20]
Coskuner I，Tekin M，Kati I，et al.Effects of dexmedetomidine on the duration of anaesthesia and wakefulness in bupivacaine epidural block[J].Eur J Anaesthesiol，2007，24（6）：535-540.
Martin E，Ramsay G，Mantz J，et al.The role of the alpha2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit[J].J Intensive Care Med，2003，18（1）：29-41.
京公网安备 11010502046607号