儿童脓毒症相关性脑病30例脑电图特征及其对评估早期病情的价值

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摘要目的探讨儿童脓毒症相关性脑病的脑电图特征及其对评估早期病情的价值。方法选取2014年1月～2015年10月本院的30例脓毒症相关性脑病患儿进行视频脑电图监测，观察其脑电图特征。患儿入组后进行多器官功能评估，分为早期和晚期脓毒症相关性脑病，并对早期与晚期的脑电图表现进行统计分析。结果脓毒症相关性脑病的脑电图表现显示，7例正常；觉醒期背景活动较同龄儿节律慢化，11例有过多θ波，8例有δ波，2例抑制或爆发抑制；生理睡眠结构存在；睡眠期偶发癫痫波，无非惊厥性癫痫持续状态。对30例早期和晚期脓毒症相关性脑病患儿的同一脑电图表现进行统计分析，结果显示，早期脑电表现正常和过多θ波的发生率显著高于晚期，而晚期δ波和抑制或爆发抑制发生率显著高于早期，差异有统计学意义（P＜0.05）。结论儿童脓毒症相关性脑病的脑电不存在特异性特征，早期和晚期脓毒性相关性脑病的脑电图表现差异有统计学意义。

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	欧阳洁明

关键词 ：脓毒症相关性脑病, 儿童, 脑电图

Abstract：Objectives To explore the electroencephalogram（EEG）characteristics of children with sepsis associated encephalopathy and its value to the evaluation of early-stage condition.Methods 30 cases of children with sepsis associated encephalopathy in our hospital from January 2014 to October 2015 were monitored using video-electroencephalogram（VEEG）to study the children′s EEG characteristics.The multiple organ function of the enrolled children was evaluated，and the children with sepsis associated encephalopathy were divided into the early-stage group and the advanced-stage group.Statistical analysis was performed on the EEG manifestation of the two groups.Results The EEG manifestation of children with sepsis associated encephalopathy showed that 7 cases were normal，the basic rhythm in the background activity during the awaking period was slower than that of the matched children，11 cases had excessive θ-rhythm，8 cases had δ-rhythm，2 cases were suppression or burst-suppression，the physiological sleep architecture existed，the epileptic waves occurred occasionally during the sleep period with no nonconvulsive status epilepticus.The same EEG findings of 30 patients with early and late sepsis associated encephalopathy were statistically analyzed，the results showed that the occurrence rate of normal status and excessive δ-rhythm in the EEG characteristics of earlystage group was higher than that in the EEG characteristics of the advanced-stage group，the occurrence rate of θrhythm and suppression or burst-suppression in the EEG characteristics of the advanced-stage group was higher than that in the EEG characteristics of the early-stage group，with significant difference（P＜0.05）.Conclusion The EEG characteristics of children with sepsis associated encephalopathy exhibit no specificity.The EEG manifestations of sepsis associated encephalopathy in the early and the advanced stages show statistically significant difference.

Key words： Sepsis associated encephalopathy Children Electroencephalogram

基金资助:广东省珠海市医学科研课题（2014003）

引用本文:

欧阳洁明. 儿童脓毒症相关性脑病30例脑电图特征及其对评估早期病情的价值[J]. 中国当代医药, 2016, 23(17): 78-80转83.
OUYANG Jie-ming. Electroencephalogram characteristics in 30 cases of children with sepsis associated encephalopathy and its value to the evaluation of early-stage condition. 中国当代医药, 2016, 23(17): 78-80转83.

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