Clinical effects observation of pioglitazone，sitagliptin and metformin combination in treating type 2 diabetes and obesity patients with poor glycemic control
XU Yu-feng LIANG Yong-qian LI Ying
Department of Endocrinology，the First People′s Hospital in Shunde District，Foshan City，Guangdong Province，Foshan 528300，China
Abstract：Objective To explore the clinical effects of pioglitazone，sitagliptin combined with metformin in treating type 2 diabetes and obesity patients with poor glycemic control.Methods 100 type 2 diabetes and obesity patients with poor glycemic control from June 2013 to June 2014 of our hospital were selected.Patients were divided into study group and control group according to random number table，and each group was 50 cases.Patients in study group were used pioglitazone，sitagliptin and metformin.Patients in control group were only used pioglitazone and metformin.All patients in two groups were treated for 3 months.The clinical index of glycated glycosylated hemoglobin（HbA1c），2 hour postprandial blood glucose（2 hPG），fasting blood glucose（FPG）and body mass index（BMI）in two groups before and after treatment were compared.After treatment，the level of fasting insulin（FINS），fasting c-peptide（CP0），postprandial 2 h insulin（2 h/INS）and postprandial 2 h C peptide（CP2）in two groups were compared.The rate of adverse effects in two groups were compared.Results After treatment，the HbA1c，2 hPG，FPG and BMI in two groups improved；and the HbA1c，2 hPG，FPG and BMI in study group was obvious better than of control group respectively after treatment（P＜0.05）.After treatment，the level of FINS，CP0，2 h/INS and CP2in study group was obvious better than that of control group respectively（P＜0.05）.The rate of adverse effects such as nausea，edema and headache compared with no statistical significance（P＞0.05）.Conclusion Conducting pioglitazone，sitagliptin and metformin combination therapy for type 2 diabetes and obesity patients with poor glycemic control can obviously control blood glucose level，decrease body′s resistance to insulin，control body weight and with definite clinical effects.It is worth to popularize in clinic.
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