Abstract：Objective To explore the relationship between N-terminal pro-brain natriuretic peptide （NT-proBNP）and coronary artery lesion degree of patients with coronary heart disease.Methods 120 proposed to diagnose coronary heart disease patients from January 2013 to January 2015 were selected as study object.All patients were divided into the positive group（n=70）and the negative group（n=50）according to coronary angiography results.The patients in positive group were divided into the simple branch lesion group （n=24），the double branch lesion group （n=25）and the multibranch lesion group （n=21）according to coronary artery lesion degree.The level of NT-proBNP between coronary angiography positive and negative patients was compared，and the level of NT-proBNP among different coronary artery lesion patients was compared.Results The level of NT-proBNP in the coronary artery lesion positive group was higher than that in the negative group，with significant difference（P＜0.01）.The level of NT-proBNP in the multi-branch lesion group was higher than that in the simple branch lesion group and the double branch lesion group，with significant difference （P＜0.01）.The level of NT-proBNP in the double lesion group was higher than that in the simple branch lesion group，with significant difference（P＜0.01）.Conclusion After eliminating the factors of heart failure，the level of NT-proBNP in coronary heart disease patients has some correlation with the serve degree of coronary artery lesions，coronary artery lesion is heavier，the higher the level of plasma NT-proBNP.
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