Abstract：ObjectiveTo analyze the therapeutic effect of Acarbose combined with Tongxinluo Capsules in coronary heart disease (CHD)patients with impaired glucose tolerance.MethodsA total of 120 patients with CHD complicated with impaired glucose tolerance admitted into our hospital were selected as research objects.They were divided into group A(n=33),group B(n=27),group C(n=31)and group D(n=29)according to the random number table method.The patients of the group A were treated with conventional treatment of secondary prevention of CHD,the patients of the group B were treated with Acarbose on the basis of the conventional treatment,the patients of the group C were treated with Tongxinluo Capsules on the basis of the conventional treatment and the patients of the group D were treated with Acarbose and Tongxinluo Capsules on the basis of the conventional treatment.The occurrence of cardiovascular events,results of coronary angiography and ratios of albumin-creatinine(UACR)within continuous half a year of follow up visits among the four groups were compared and analyzed.ResultsThe basic heart rate,body mass index,systolic pressure,diastolic blood pressure,blood lipid(total cholesterol,low density cholesterol and triglycerides),fasting blood-glucose and blood-glucose of 2 h after 75 g oral glucose,UACR and other general datas were compared of patients of the four groups,the differences were not statistically significant(P＞0.05).The results of coronary angiography were compared in four groups,the differences were not statistically significant(P＞0.05).After six months of follow-up,the UACR in group D was significantly lower than that of group B and C,and the differences were statistically significant(P＜0.05).The incidence of cardiovascular events in group A was higher than that in group B,C and D,and incidence of cardiovascular events in group D was lowest,the differences were statistically significant(P＜0.05).The incidence of cardiovascular events was compared in group B,C and D,the differences were not statistically significant(P＞0.05).ConclusionFor CHD patients with impaired glucose tolerance,combination of Acarbose and Tongxinluo Capsules can obtain a remarkable effect.The effect is better than single medication.It is beneficial to reduce the UACR level and reduce the incidence of adverse cardiovascular events,it is worth promoting the application.
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