Study on association between serum liver enzymes and metabolic syndrome
WU Di-yun1 CHEN Yan-hong2 TANG Jian-hui1
1. Department of Health Management, the Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People′s Hospital
2. Department of Pediatric Outpatient and Emergency, the Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People′s Hospital
Abstract：Objective To explore the association between serum liver enzymes and metabolic syndrome (MS). Methods A total of 2232 people who had physical examination in the Physical Examination Center of Qingyuan People′s Hospital were selected as study subjects from January to December 2019. They were divided into MS group and non-MS group according to whether they had MS or not. The levels of liver enzymes were compared between the two groups, the correlation of three liver enzymes with MS and its components, and their screening effect on MS were analyzed. Results There were 586 cases in the MS group and 1646 cases in the non-MS group, and the prevalence of MS in the study population was 26.25%. The liver enzyme level of MS group was higher than that of non-MS group, the difference was statistically significant (P＜0.05). In female, alanine aminotransferase (ALT) was associated with waist circumference and serum triglyceride (TG), while γ-glutamyl transferase (GGT) was associated with fasting blood glucose and TG. In male,ALT was associated with waist circumference, diastolic blood pressure and high-density lipoprotein cholesterol, while GGT was associated with waist circumference, TG and diastolic blood pressure (|r|＞0.2, P＜0.05). There was significant correlation between the MS risk and the levels of ALT and GGT in male, and GGT in female (P＜0.05). GGT could be used to screen the MS, and the possibility best critical values were respectively 15.5 U/L in female and 28.5 U/L in male. Conclusion Among the three liver enzymes, GGT has the closest relationship with MS, and GGT can better screen the possibility of MS disease.
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