Comparison of ambulatory blood pressure and traditional Chinese medicine syndromes in patients with essential hypertension complicated with metabolic syndrome and non-metabolic syndrome
CHEN Yi1 DENG Yue-yi1 FU De-yu2 WANG Wen-jian3
1.Department of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China;
2.Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;
3.Department of Integrated Traditional Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
Abstract：Objective To observe the difference of ambulatory blood pressure and traditional Chinese medicine (TCM)syndrome between patients with metabolic syndrome (MetS) and non-metabolic syndrome (no-MetS) hypertension.Methods From December 1, 2011 to January 31, 2015, 59 patients with essential hypertension complicated with MetS(MetS group) and 60 patients with essential hypertension but without complications of MetS (no-MetS group) from the Department of Nephrology in Longhua Hospital, Shanghai University of Traditional Chinese Medicine, and the Department of Hypertension Specialist, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine were enrolled.The physiology indexes (body weight, body mass index, waist circumference, waist -to -hip ratio, homeostatic model assessment for insulin resistance [HOMA -IR]), glucose metabolism indexes (fasting blood glucose [FPG], fasting insulin [FPI], glycosylated hemoglobin [HbA1c], 2 hours postprandial blood glucose [2 h PPG]), blood lipid indicators (cholesterol [TC], triglyceride [TG], high density lipoprotein cholesterol [HDL-C], low density lipoprotein cholesterol [LDL-C]) and diastolic blood pressure (DBP), systolic blood pressure (SBP), mean arterial pressure (MAP) at various time periods (24 h, day [d], and night [n]) and variability (v) blood pressure indicators of the two groups were measured.The TCM syndrome scores were counted.Results The physiology index of the patients in the MetS group was significantly higher than that in the no-MetS group, and the difference was statistically significant (P<0.01).The levels of FPG, 2 h PPG, HbA1c and FPI in the MetS group were significantly higher than those in the no-MetS group, and the HDL-C level was significantly lower than that in the no-MetS group, with statistically significant differences (P<0.01).The levels of TC, TG and LDL-C in the MetS group were higher than those in the no-MetS group, and the differences were statistically significant (P<0.05).The 24 h MAP, dDBP, dMAP and nDBP in the MetS group were higher than those in the no-MetS group, and the differences were statistically significant (P<0.05).There were no significant differences in 24 h SBP, 24 h DBP, dSBP, nSBP and nMAP between the two groups (P>0.05).The nDBPv of the MetS group was higher than that of the no-MetS group, and the difference was statistically significant (P<0.05).There were no significant differences in the other blood pressure variability indexes between the two groups (P>0.05).The TCM syndrome of MetS hypertensive patients was mainly characterized by accumulation of qi deficiency complicated with heat depression, phlegm dampness, and blood stasis.The disease location was in the spleen and related to the liver and kidney.Conclusion Compared with no-MetS hypertensive patients, MetS hypertensive patients are susceptible to more serious cardiovascular risk.Focus on boosting qi, fortifying the spleen and removing accumulation is an effective intervention in TCM.
陈熤; 邓跃毅; 符德玉; 王文健. 原发性高血压合并代谢综合征与非代谢综合征患者动态血压及中医证候的比较[J]. 中国当代医药, 2019, 26(14): 185-189.
CHEN Yi; DENG Yue-yi; FU De-yu; WANG Wen-jian. Comparison of ambulatory blood pressure and traditional Chinese medicine syndromes in patients with essential hypertension complicated with metabolic syndrome and non-metabolic syndrome. 中国当代医药, 2019, 26(14): 185-189.
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