Abstract：Objective To investigate the relationship between serum markers of Down′s syndrome screening and pathological pregnancy in the second trimester of pregnancy.Methods Altogether 873 pregnant women who were treated in Daxing District Maternal and Child Health Hospital of Beijing City from January 2016 to December 2018 were selected as the subjects.The upper quartile of alpha-fetoprotein (AFP)and human chorionic gonadotropin (β-hCG)levels of pregnant women included in the study was taken as the cut-off point,based on which all the patients were divided into the elevated group and the normal group.The lower quartile of the free estriol(uE3)concentration of pregnant women included in the study was taken as the cut-off point,based on which the patients were divided into the lowered group and the normal group.The incidence of pathological pregnancy was compared among pregnant women in different AFP,β-hCG and uE3 groups.Results Of all the pregnant women,123 cases had elevated AFP and 750 cases had normal AFP.The incidence of pathological pregnancy in the elevated AFP group was higher than that in the normal AFP group(P＜0.05).Of all the pregnant women,147 cases had elevated β-hCG and 726 cases had normal β-hCG.The incidence of pathological pregnancy in the elevated AFP group was higher than that in the normal AFP group(P＜0.05).Of all the pregnant women,267 cases had decreased uE3 and 606 cases had normal uE3.The incidence of pathological pregnancy in the lowered uE3 reduction group was higher than that of normal uE3 group (P＜0.05).Conclusion The serum markers of AFP,β-hCG and uE3 in Down′s screening for the second trimester of pregnancy has certain guiding significance for pathological pregnancy.
郭方方. 孕中期唐氏筛查血清标志物结果与病理妊娠的关系[J]. 中国当代医药, 2019, 26(17): 92-94.
GUO Fang-fang. Relationship between serum markers of Down′s syndrome screening and pathological pregnancy in the second trimester of pregnancy. 中国当代医药, 2019, 26(17): 92-94.
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