Clinical significance of detection of plasma D-dimer and fibrinogen in the diagnosis of disseminated intravascular coagulation
CAI Jin-mei1 HUANG Xue-zhen1 ZHANG Rui-xiong1 WU Sheng-xing2
1.Clinical Laboratory,Xiaolan Hospital Affiliated to Southern Medical University,Guangdong Province,Zhongshan 528415,China;2.Clinical Laboratory,Chenxinghai Hospital of Zhongshan City in Guangdong Province,Zhongshan 528415,China
摘要目的 探讨血浆D-二聚体及纤维蛋白原检测在诊断弥散性血管内凝血方面疾病的临床价值。方法 选择2014年1月～2017年5月我院收治的30例弥散性血管内凝血患者作为观察组，选择同期收治的30例健康体检妇女作为对照A组，选择30例疑为弥散性血管内凝血的正常妊娠妇女作为对照B组。比较三组患者的血浆D-二聚体和纤维蛋白原水平。结果 治疗前，观察组的血浆D-二聚体及纤维蛋白原水平分别为（2301.52±1367.94）μg/L、（1.23±0.34）g/L，对照 A 组分别为（143.67±35.12）μg/L、（2.76±0.47）g/L，对照 B 组分别为（874.98±451.20）μg/L、（2.11±0.36）g/L。观察组的血浆D-二聚体水平显著高于对照A、B组，但纤维蛋白原水平显著低于对照A、B组，差异均有统计学意义（P＜0.05）；对照B组的血浆D-二聚体显著高于对照A组，纤维蛋白原水平显著低于对照A组，差异有统计学意义（P＜0.05）。结论 血浆D-二聚体及纤维蛋白原检测在诊断弥散性血管内凝血方面有较高的临床价值，诊断敏感性较强，值得临床推广应用。
Abstract：Objective To investigate the clinical value of plasma D-dimer and fibrinogen in the diagnosis of disseminated intravascular coagulation(DIC).Methods A total of 30 DIC patients admitted into our hospital from January 2014 to May 2017 were selected as the observation group.The other 30 healthy women for physical examinations were enrolled in the same period as the control group A and another 30 normal pregnant women with suspected DIC was classified into the control group B.The plasma D-dimer and fibrinogen levels were compared among the three groups.Results Before treatment,the levels of plasma D-dimer and fibrinogen in the observation group were(2301.52±1367.94)μg/L and (1.23±0.34)g/L respectively,while those in the control groups A and B were(143.67±35.12)μg/L and(2.76±0.47)g/L,and(874.98±451.20)μg/L and (2.11±0.36)g/L accordingly.The D-dimer level in the observation group was significantly higher,but fibrinogen was lower than those in the other two groups,with statistical differences(P＜0.05).The D-dimer level in the control group B was higher compared to the control group A,the fibrinogen level of the control group B was lower compared to the control group A,with statistical significance (P＜0.05).Conclusion The detections of plasma D-dimer and fibrinogen have high clinical values in the diagnosis of DIC and the diagnostic sensitivity is strong,which is worthy of clinical application and promotion.
蔡锦梅;黄雪珍;张瑞雄;吴胜星. 血浆D-二聚体及纤维蛋白原检测在诊断弥散性血管内凝血方面疾病的临床意义[J]. 中国当代医药, 2018, 25(9): 114-116.
CAI Jin-mei;HUANG Xue-zhen;ZHANG Rui-xiong;WU Sheng-xing. Clinical significance of detection of plasma D-dimer and fibrinogen in the diagnosis of disseminated intravascular coagulation. 中国当代医药, 2018, 25(9): 114-116.
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