Abstract：Objective To investigate the effect of Nimodipine on serum neurotransmitters in hypertensive intracerebral hemorrhage and its prognostic.Methods From June 2016 to June 2017,108 patients with hypertensive intracerebral hemorrhage were diagnosed in our hospital were selected as subjects.They were divided into observation group(56 cases)and control group (52 cases)according to different medication schemes.The patients in the observation group were treated with Nimodipine combined with Xingnaojing,and the control group was treated with the treatment of Edaravone and Xingnaojing,and two courses of treatment were successively treated.The serum neurotransmitter indexs,neurofunctional indexs,survival quality score and therapeutic effect were compared between the two groups.Results After two courses of treatment,the vasopressin([7.18±1.59]ng/L),glial fibrillary acidic protein([7.28±2.16]ng/L),glutamate([77.57±3.59]μmol/L)μmol/L,aspartic acid([28.69±3.67]μmol/L),S100B protein([0.44±0.06]ng/L),neuropeptide Y([177.45±11.07]μg/L),neuron-specific enolase([10.19±2.65]mg/L)in the observation group were significantly lower than those in the control group ([10.27±3.01]ng/L,[13.24±2.62]ng/L,[84.34±6.52]μmol/L,[37.95±4.95]μmol/L,[0.87±0.31]ng/L,[196.34±12.64]μg/L,[16.08±4.12]mg/L),while the γ-aminobutyrate([4.25±1.02]μmol/L)and brain origin neurotrophic factor([6.21±1.26]ng/mL)in the observation group were significantly higher than those in the control group ([3.41±0.58]μmol/L,(5.13±1.05]ng/mL),and the differences were statistically significant(P＜0.05).The total score of world health organization survival quality measurement scale (WHOQOL-100)in the observation group was (78.55±7.53)points,which was significantly higher than that in the control group (71.05±6.15)points,and the difference was statistically significant(P＜0.05).The effective rate of treatment in the observation group(89.29%)was significantly higher than that in the control group(80.77%),and the difference was statistically significant(P＜0.05).Conclusion Nimodipine and Xingnaojing are suitable for the treatment of hypertensive intracerebral hemorrhage.It can effectively regulate the expression level of serum neurotransmitters,promote the recovery of nerve function,and have a good prognosis.
耿煜. 尼莫地平联合醒脑静治疗高血压脑出血患者的临床效果[J]. 中国当代医药, 2018, 25(9): 83-86.
GENG Yu. Effect of Nimodipine combined with Xingnaojing for the treatment of hypertensive intracerebral hemorrhage. 中国当代医药, 2018, 25(9): 83-86.
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