Clinical efficacy study of Montelukast Sodium of leukotriene receptor antagonist on acute asthmatic bronchitis in children
WU Zhuo-jian1 ZHONG Mei-gong1 TAN Wen-qiang1 LI Jun-wen2 XU Jie2 LIANG Fa-liang1 FENG Yue-hua
1.Department of Pharmacy,Jiangmen Maternal and Child Health Hospital,Guangdong Province,Jiangmen 529000,China;
2.Department of Pediatrics,Jiangmen Maternal and Child Health Hospital,Guangdong Province,Jiangmen 529000,China
Abstract：Objective To investigate the clinical efficacy of Montelukast Sodium of leukotriene receptor antagonist on children with acute asthmatic bronchitis. Methods A total of 80 children with acute asthmatic bronchitis admitted to our hospital from January 2018 to June 2019 were selected and divided into the observation group (40 cases) and the control group (40 cases) according to the different treatment methods.The control group was treated with routine treatment,the observation group was treated with Montelukast Sodium of leukotriene receptor antagonist on this basis.The clinical efficacy,the time of clinical symptom relief,the recurrence rate of wheezing,inflammatory mediators and the safety of treatment were compared between the two groups. Results The total effective rate of the observation group was 95.00%,which was higher than that of the control group (77.50%),the difference was statistically significant (P＜0.05).The recurrence rate of wheezing was 5.00% in the observation group within 6 months after treatment,which was lower than 25.00% in the control group,the difference was statistically significant (P＜0.05).The wheezing relief time,wheezing disappeared time,cough subsided time and hospitalization time in the observation group were shorter than those in the control group,the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) of the observation group were lower than those of the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion The treatment of Montelukast Sodium of leukotriene receptor antagonists in children with acute asthmatic bronchitis can effectively improve the clinical efficacy,promote the relief of clinical symptoms,improve the inflammatory response,reduce the recurrence of asthma,and have a high safety.
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