Clinical effect of Lecithin Tablets in the treatment of Alzheimer′s disease
LIU Zheng1 LIU Bo-wen2
1.Epilepsy Diagnosis and Treatment Center,First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin 150000,China;
2.Graduate School of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin 150000,China
Abstract：Objective To evaluate the efficacy of Lecithin Tablets in the treatment of mild and moderate Alzheimer′s disease(AD).Methods A total of 118 patients with mild to moderate AD admitted to the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from January 2019 to January 2020 were selected and divided into observation group and control group according to the random number table method,with 59 cases in each group.The control group received conventional treatment,and the observation group received Lecithin Tablets treatment on the basis of the control group.Both groups received continuous medication for 12 weeks.The clinical efficacy of the two groups was observed and compared,the clinical memory scale was used to evaluate and compare the memory scores of the two groups,the ability of daily living(ADL)was used to assess and compare the ability of daily living of the two groups,and the dementia deficit scale(ADS)was used to evaluate and compare the two Group dementia degree,observe and compare the occurrence of adverse reactions between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).Before treatment,there was no significant difference in the scores of the clinical memory scales between the two groups(P＞0.05);after 12 weeks of treatment,the clinical memory scale scores of the observation group were higher than those before the treatment,the differences were statistically significant(P＜0.05).After 6 and 12 weeks of treatment,the ADL and ADS scores of the two groups were lower than those of before treatment,and the observation group was lower than that of the control group in the same period,the differences were statistically significant(P＜0.05).There were no abnormal findings in the laboratory liver and kidney functions and the three major routine examinations before and after treatment in the two groups.Conclusion It had certain clinical effect on Lecithin Tablets in the treatment of mild and moderate AD,and the clinical memory scale,ADL and ADS scores have been effectively improved,which has certain security.
刘征;刘博文. 卵磷脂片治疗阿尔茨海默病的临床效果[J]. 中国当代医药, 2021, 28(13): 92-95.
LIU Zheng;LIU Bo-wen. Clinical effect of Lecithin Tablets in the treatment of Alzheimer′s disease. 中国当代医药, 2021, 28(13): 92-95.
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