Abstract：Objective To explore the clinicopathological features of Fas-related death domain proteins expression in breast cancer.Methods From February 2013 to February 2017,148 cases of paraffin-embedded tissue specimens from patients undergone tumor surgeries were selected.There were benign breast lesions in 26 cases(group A),breast cancer without lymph node metastasis in 58 cases(group B),and breast cancer with lymph node metastasis in 64 cases(group C).All specimens were performed with immunohistochemical examinations in order to analyze the proteins expression of Fas-related death domain.Results It was detected that Fas-related death domain proteins were expressed in the intracytoplasm of breast cancer cells and epithelial cells of benign breast lesions.In group B,the expression of Fas-related death domain proteins was weak and dyeing range and depth were small compared with those in groups of A and C,which were in slight expression and deep dyeing.The positivity expression rates of Fas-related death domain proteins in groups of A,B,and C were 88.5%(23/26),46.6%(27/58),and 65.6%(42/64)respectively.The positivity expression rate in group A was higher than that in groups of B and C with statistical differences(P＜0.05).For breast cancer patients,lymph node metastasis and age with a definite diagnosis were associated with Fas-related death domain protein expression(P＜0.05).However,the clinical stage and histological type were not related to the expression of Fas-related death domain protein (P＞0.05).Conclusion The expression of Fas-related death domain proteins is closely related to the lymph node metastasis and age with a definite diagnosis of breast cancer,but it has nothing to do with the clinical stage and histological type,to which should be paid high attention.
吴嘉. Fas相关死亡结构域蛋白在乳腺癌中表达的临床病理研究[J]. 中国当代医药, 2017, 24(28): 4-6.
WU Jia. Clinicopathological study of Fas-related death domain protein expression in breast cancer. 中国当代医药, 2017, 24(28): 4-6.
京公网安备 11010502046607号