Abstract：Objective To investigate the clinical effect of low dose Aminophylline combined with Fluticasone inhalation in the treatment of severe stable chronic obstructive pulmonary disease (COPD).Methods A total of 132 patients with severe stable COPD admitted to our department from January 2016 to April 2018 were selected as the study subjects,they were divided into observation group (66 cases) and control group (66 cases) according to the random number table method.Both groups were given Fluticasone Aerosol inhalation, the observation group was given low dose Aminophylline Sustained-Release Tablets orally, while the control group was given Salbutamol Aerosol inhalation, both groups were treated for 6 months.The pulmonary function indexes (forced vital capacity [FVC], forced expiratory volume in the first second [FEV1], forced expiratory volume in the first second and forced vital capacity specific value[FEV1/FVC], percentage of FEV1 to the predicted value [FEV1%]), 6 minutes walking distance (6MWD), quality of life score (SGRQ), dyspnea score (mMRC) and adverse reactions were compared between the two groups.Results The FVC,FEV1, FEV1/FVC and FEV1% of the two groups after treatment were significantly higher than those before treatment,the differences were statistically significant (P<0.05).The FVC, FEV1, FEV1/FVC and FEV1% in the observation group were significantly higher than those in the control group, the differences were statistically significant (P<0.05).The 6MWD of the two groups after treatment was significantly higher than that before treatment, and the SGRQ score and mMRC score were significantly lower than those before treatment, the differences were statistically significant (P<0.05).After treatment, the 6MWD of the observation group was significantly higher than that of the control group, and the SGRQ score and mMRC score were significantly lower than those of the control group, the differences were statistically significant (P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion Low-dose Aminophylline combined with inhalation of Fluticasone Aerosol is effective in the treatment of severe stable COPD.It can effectively improve the pulmonary function, exercise tolerance and quality of life of patients.It is worthy of clinical promotion and application.
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