Abstract：Objective To investigate the application effect of transnasal high flow humidification oxygen therapy(HHFNC)in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods From October 2017 to October 2018,85 patients with acute exacerbation of COPD treated in respiratory department of our hospital were selected as the subjects of study.They were divided into control group(n=42)and study group(n=43)by the random number table method.The patients in the control group were treated with noninvasive positive pressure ventilation for respiratory support,while the study group was treated with HHFNC for respiratory support.The changes of respiratory frequency(R),arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2)and oxygen index(OI)after treatmentwere compared between the two groups.The rate ofmechanical ventilation of tracheal intubation,treatment compliance and treatment complications were counted.Results The R and PaCO2 of the two groups after treatmentwere lower than those before treatment,PaO2 and OIwere higher than those before treatment,the differences were statistically significant(P＜0.05).Therewere no significant differences in R,PaCO2,PaCO2 and OIbetween the two groups after treatment(P＞0.05).There was no significant difference in the rate ofmechanical ventilation of tracheal intubation between the two groups(P＞0.05).The treatment compliance of the study group was higher than that of the control group,and the total incidence of complicationswas lower than that of the control group,the differences were statistically significant(P＜0.05).Conclusion Respiratory support therapy with HHFNC in patients with acute exacerbation of COPD can effectively improve the ventilation function of patients,and the compliance of patients is good and the complications are few,so it is valuable to popularize and apply.
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