雾化吸入与静脉注射戊乙奎醚对大容量肺灌洗术患者灌洗侧肺术前的效果

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摘要目的探讨雾化吸入与静脉注射戊乙奎醚对大容量肺灌洗术患者灌洗侧肺术前的效果。方法选取我院肺尘埃沉着病一病区、二病区2018年1月～2019年6月收治的109例需行大容量肺灌洗术患者作为研究对象，按就诊先后顺序分为实验组（50例）和对照组（59例）。实验组给予雾化吸入戊乙奎醚，对照组给予静脉注射戊乙奎醚治疗。观察两组患者灌洗结束后30 min（T1）、60 min（T2）、90 min（T3）的气道峰压及肺顺应性，比较两组患者手术前后的肺功能（FVC、FEV1、PEF）情况和动脉血气指标（PaO2、PaCO2）。结果两组T2 和T3时的气道峰压均低于T1时，两组T2 和T3时的肺顺应性均高于T1时，差异有统计学意义（P＜0.05）。实验组T2 和T3时的气道峰压均低于对照组，差异有统计学意义（P＜0.05）；实验组T2 和T3时的肺顺应性均高于对照组，差异有统计学意义（P＜0.05）。实验组患者术后的PEF、FVC、FEV1水平高于对照组，差异有统计学意义（P＜0.05）。实验组术后的PaO2水平明显高于对照组，PaCO2水平明显低于对照组，差异有统计学意义（P＜0.05）。结论大容量肺灌洗术患者灌洗侧肺术前雾化吸入或静脉注射戊乙奎醚的临床治疗效果理想，提高患者术后不同时间点肺顺应性，降低患者气道峰压，提高肺功能。

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	韦云海

关键词 ：大容量肺灌洗术, 雾化吸入, 静脉注射, 戊乙奎醚

Abstract：Objective To investigate the effect of nebulized inhalation and intravenous Penehyclidine on preoperative lavage of side lung in patients with large volume lung lavage.Methods A total of 109 patients who needed to be treated with large volume lung lavage admitted to the First and Second ward of pneumoconiosis in our hospital from January 2018 to June 2019 were selected as the study objects, the patients were divided into the experimental group (50 cases)and the control group (59 cases) according to the order of treatment.The experimental group was given nebulized inhalation of Penehyclidine, and the control group was given intravenous injection of Penehyclidine.The peak airway pressure and pulmonary compliance of the two groups were observed at 30 min (T1), 60 min (T2) and 90 min (T3) after lavage.The pulmonary function (FVC, FEV1, PEF) and arterial blood gas (PaO2, PaCO2) of the two groups were compared before and after operation.Results The peak airway pressures at T2 and T3 in the two groups were lower than those at T1, the pulmonary compliance at T2 and T3 in the two groups were higher than those at T1, the differences were statistically significant (P＜0.05).The peak airway pressure at T2 and T3 in the experimental group was lower than that in the control group, the difference was statistically significant (P＜0.05).The pulmonary compliance of the experimental group at T2 and T3 was higher than that of the control group, the difference was statistically significant (P＜0.05).The level of PEF, FVC, FEV1 in the experimental group after operation were higher than those in the control group, the differences were statistically significant (P＜0.05).The level of PaO2 in the experimental group after operation was significantly higher than that in the control group, and the level of PaCO2 in the experimental group after operation was significantly lower than that in the control group, the difference was statistically significant (P＜0.05).Conclusion The clinical treatment effect of atomization inhalation or intravenous injection of Penehyclidine in the lavage side of patients with large volume lung lavage before operation is ideal, which can improve the pulmonary compliance at different time points after operation, reduce the peak airway pressure and improve the pulmonary function.

Key words： Large volume lung lavage Nebulization;Intravenous injection Penehyclidine

作者简介: 韦云海（1986-），男，广西都安人，本科，主治医师，研究方向：肺容量大灌洗

引用本文:

韦云海. 雾化吸入与静脉注射戊乙奎醚对大容量肺灌洗术患者灌洗侧肺术前的效果[J]. 中国当代医药, 2020, 27(12): 125-128.
WEI Yun-hai. Effect of nebulized inhalation and intravenous Penehyclidine on preoperative lavage of side lung in patients with large volume lung lavage. 中国当代医药, 2020, 27(12): 125-128.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2020/V27/I12/125

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