Abstract：Objective To study the risk factors for the occurrence of capillary leak syndrome in patients with sepsis.Methods A total of 100 patients with sepsis treated in our hospital from October 2017 to September 2018 were selected as the subjects.According to whether suffering from the complication of capillary leak syndrome, the patients were divided into the leakage group (n=13, with the complication of capillary leak syndrome) and non-leakage group (n=87,without complication of capillary leak syndrome).The clinical data of the two groups were compared and analyzed.The risk factors of capillary leak syndrome in patients with sepsis were also analyzed.Results For patients in the leakage group, the levels of procalcitonin (PCT), C-reactive protein (CRP), angiopoietin-2 (Ang2), angiopoietin receptor 2 antibody (Tie2), fasting blood glucose and lactic acid, and the score of sepsis-related organ failure assessment (SOFA) were higher than those of the non-leakage group, and the angiopoietin-1 (Ang1) level was lower than that of the non-leakage group, the incidence of coagulation disorders and multiple organ dysfunction syndrome (MODS) involved with three organs or more was higher than that of non-leakage group, and the state of sepsis was more serious than that of the non-leakage group, the differences were statistically significant (P＜0.05).Logistic multivariate analysis showed that the level of Ang1 decreased (β=0.363, OR=1.247, 95%CI [1.121, 1.697]), the levels of Ang2 (β=0.964, OR=1.356, 95%CI[1.135, 1.896]) and Tie2 receptor increased [β=0.891, OR=1.289, 95%CI [1.127, 1.731]), high lactic acid level (β=0.569, OR=1.256, 95%CI [1.112, 1.863]), high SOFA score (β=0.921, OR=1.264, 95%CI [1.125, 1.896]), the state of sepsis was severe [β=0.634, OR=1.446, 95%CI [1.141,1.934]), the organs involved by MODS was three or more(β=0.697, OR=1.446, 95%CI [1.256, 1.943]) were risk factors for the occurrence of capillary leak syndrome in patients with sepsis (P＜0.05).Conclusion The decreased Ang1 level, and elevated Ang2 and Tie2 receptor levels, high level of serum lactate, high score of SOFA, severe sepsis, three or more organs involved by MODS are all the risk factor for the occurrence of capillary leak syndrome in patients with sepsis.
杨文韬； 林棱； 陈凝. 脓毒症患者并发毛细血管渗漏综合征的危险因素分析[J]. 中国当代医药, 2020, 27(8): 26-28转36.
YANG Wen-tao； LIN Leng； CHEN Ning. Analysis of risk factors for the occurrence of capillary leak syndrome in patients with sepsis. 中国当代医药, 2020, 27(8): 26-28转36.
京公网安备 11010502046607号