拉贝洛尔与硫酸镁联合治疗对子痫前期患者妊娠结局的影响

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摘要目的探讨拉贝洛尔与硫酸镁联合治疗对子痫前期患者妊娠结局的影响。方法选取2016年8月～2018年3月我院收治的210例子痫前期患者作为研究对象，按照随机数字表法将其分成联合组与基础组，每组各105例。基础组患者采取单纯硫酸镁治疗，联合组患者予以拉贝洛尔与硫酸镁联合治疗。比较两组患者的治疗效果、妊娠结局情况、不良反应发生情况及治疗前后血压与尿蛋白定量。结果两组患者治疗前的血压（舒张压、收缩压）与24 h尿蛋白定量比较，差异无统计学意义（P＞0.05）；两组患者治疗后的血压与24 h尿蛋白定量均低于治疗前，差异有统计学意义（P＜0.05）；联合组患者治疗后的血压及24 h尿蛋白定量均低于基础组，差异有统计学意义（P＜0.05）。联合组患者的治疗总有效率为96.2%，显著高于基础组的78.1%，差异有统计学意义（P＜0.05）。联合组患者的宫缩乏力、早产、胎儿窘迫、新生儿窒息、产后感染、产后出血的发生率均低于基础组，差异有统计学意义（P＜0.05）。两组患者的不良反应总发生率比较，差异无统计学意义（P＞0.05）。结论子痫前期患者采用拉贝洛尔与硫酸镁联合治疗，效果甚佳，可改善患者的妊娠结局，值得在临床上推广。

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	谢芳

关键词 ：子痫前期, 拉贝洛尔, 硫酸镁, 妊娠结局, 血压

Abstract：Objective To investigate the effect of combined treatment of Labetalol and Magnesium Sulfate on pregnancy outcome in patients with preeclampsia.Methods Altogether 210 patients with preeclampsia admitted to our hospital from August 2016 to March 2018 were selected as research objects and they were divided into the combined group and basic group according to the random number table method,with 105 cases in each group.The patients in the basic group were treated with Magnesium Sulfate alone,and the patients in the combined group were treated with Labetalol and Magnesium Sulfate.The therapeutic effect,pregnancy outcomes,adverse reactions,and blood pressure and urine protein quantitation before and after treatment were compared between the two groups.Results There were no significant differences in blood pressure(diastolic blood pressure,systolic blood pressure)and 24 h urine protein quantitation between the two groups before treatment(P＞0.05).The blood pressure and 24 h urine protein quantitation after treatment in the two groups were lower than those before treatment,and the differences were statistically significant(P＜0.05).The blood pressure and 24 h urine protein quantitation after treatment in the combined group were lower than those in the basic group,and the differences were statistically significant(P＜0.05).The total effective rate of treatment in the combined group was 96.2%,which was significantly higher than that in the basic group(78.1%),and the difference was statistically significant (P＜0.05).The incidence rates of uterine atony,premature delivery,fetal distress,neonatal asphyxia,postpartum infection,and postpartum hemorrhage in the combined group were lower than those in the basic group,and the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence rate of adverse reactions between the two groups(P＞0.05).Conclusion Labetalol combined with Magnesium Sulfate is effective in treatment of patients with preeclampsia,and it can improve the pregnancy outcome of patients,which is worthy of clinical promotion.

Key words： Preeclampsia Labetalol Magnesium Sulfate Pregnancy outcome Blood pressure

引用本文:

谢芳. 拉贝洛尔与硫酸镁联合治疗对子痫前期患者妊娠结局的影响[J]. 中国当代医药, 2019, 26(2): 123-126.
XIE Fang. Effect of combined treatment of Labetalol and Magnesium Sulfate on pregnancy outcome in patients with preeclampsia. 中国当代医药, 2019, 26(2): 123-126.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2019/V26/I2/123

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