Abstract：Objective To study the content and correlation of cadmium in blood,synovium,cartilage and subchondral bone of rabbits after drinking water with cadmium gradually.Methods Twenty-eight New Zealand white rabbits (equal proportion of male to female) aged two and a half months old,were randomly selected from female and male groups alternatively.They were divided into control group and experimental group,14 rabbits in each group.They were fed in every single cage.In the control group,rabbits were fed with normal drinking water,and in the experimental group,they were fed with water containing 40 mg/L cadmium chloride.After three months,all rabbits were sacrificed.The cadmium content in the specimens was determined by atomic absorption spectrometry.Results The cadmium content in the blood,synovium，cartilage and subchondral bone of the experimental group was significantly higher than that of the control group (P<0.05).The cadmium content of the articular cartilage in the experimental group was positively correlated with the cadmium content in the subchondral bone,synovium and blood (r=0.959,0.556,0.942;P<0.05),respectively.ConclusionChronic poisoning of drinking water containing cadmium can cause cadmium accumulation in blood,synovium,articular cartilage and subchondral bone.Cadmium in articular cartilage is derived from subchondral bone,synovium,and blood,but mainly from subchondral bone.Cadmium accumulates in these tissues and may eventually lead to osteoarthritis.
Burman A，Haworth O，Bradfield P，et al.The role of leucytestromal interactions in chronic inflammatory joint disease[J].Joint Bone Spine，2005，72（1）：10-16.
Radin EL，Rose RM.Role of subchondral bone in the initiation and progression of cartilage damage[J].Clin Orthop Relat Res，1986，（213）：34-40.
[8]
陈晓.镉致骨毒效应及预后[D].上海：复旦大学，2010.
[9]
钱海雷.氟、镉对骨的效应[D].上海：复旦大学，2006.
[10]
Bobinac D，Spanjol J，Zoricic S，et al.Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans[J].Bone，2003，32（3）：284-290.
[11]
Azzonuzi BE，Tsangaris GT，Pellegrini O，et al.Cadmium induces apoptosis in a human T cell line[J].Toxicology，1994，88（1-3）：127-139.
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