Abstract：Objective To observe the effect of sublingual allergen specific immunotherapy on allergic asthma in children.Methods A total of 58 cases children with allergic asthma treated in our hospital from October 2016 to October 2017 were selected as the subjects,and all the children were randomly divided into the observation group and the control group,with 29 cases in each group.The control group was treated with Inhaled Budesonide Aerosol,and the observation group was given Dermatophagoides Farinae Drops by sublingual administrntion.The changes of serum interferon gamma(IFN-gamma)and interleukin-4(IL-4)were compared before and after treatment,and the effect of clinical treatment was compared.Results The levels of IFN-gamma and IL-4 in the two groups were significantly improved after treatment compared with those before treatment(P＜0.05).After treatment,the level of IFN-gamma in the observation group was higher than that in the control group,and the IL-4 level was lower than that in the control group,the differences were statistically significant (P＜0.05).The total effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion The treatment of sublingual Dermatophagoides Farinae Drops specific immunotherapy in the treatment of allergic asthma in children is beneficial to improve the symptoms of asthma in children.It is effective in clinical treatment,and is worthy of further clinical application.
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