Abstract：Objective To investigate the effect of Allopurinol in the treatment of acute cerebral ischemic stroke complicated with carotid artery plaque.Methods One hundred and twenty patients with acute cerebral ischemic stroke complicated with carotid plaque were enrolled from January to September in 2017.They were randomly divided into the control group and the observation group,with 60 cases in each group.In the control group,Atorvastatin in combination with Aspirin Enteric-coated Tablets was used,while in the observation group,Allopurinol was added on the basis of the control group.The change of carotid plaque before and after treatment and therapeutic effect were compared between two groups.Results There was no significant difference in the property of plaque before treatment between two groups (P＞0.05).The incidence of stable plaques after treatment in two groups was higher than that before treatment,and the difference was statistically significant(P＜0.05).The incidence of stable plaques in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the plaque area before treatment between the control group ([0.24±0.12]cm2)and the observation group([0.23±0.11]cm2)(P＞0.05).The plaque area in the observation group([0.17±0.07]cm2)after treatment was significantly smaller than that in the control group ([0.21±0.09]cm2),and the difference was statistically significant(P＜0.05).The total effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the level of uric acid before treatment between the observation group ([528±58]μmol/L)and the control group([530±60]μmol/L)(P＞0.05).The level of uric acid after treatment in the observation group was(416±94)μmol/L,which was significantly lower than that before treatment and was lower than that in the control group of(525±57)μmol/L,with statistically significant difference(P＜0.05).During the treatment,2 cases(3.3%)in the observation group had an increase in the level of glutamate aminotransferase 2 times more than the normal upper limit.No adverse reactions occurred in the control group.There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion Allopurinol has a significant effect in the treatment of acute cerebral ischemic stroke complicated with carotid artery plaque.It can effectively stabilize carotid plaque and reduce plaque area,which is worthy of promotion.
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