Abstract：Objective To investigate the clinical effect of high intensity focused ultrasound in the treatment of allergic rhinitis and its influence on the IL-2,IL-4,IL-10,IFN-γ and histamine content.Methods Fifty patients with AR treated by Otolaryngology Department of Chaozhou Central Hospital from June 2013 to December 2016 were selected as the research group and 30 healthy people were selected as the control group at the same period.The symptom score,the results of the nasal resistance before and 6 months after treatment in patients of the research group were compared,while the IL-2,IL-4,IL-10,IFN-γ and histamine content in the research group before treatment and after 6 months treatment were compared with those in the control group.Results Each symptom score before treatment and after 6 months treatment in the research group were compared with significant differences(P＜0.05).The efficacy index showed that 38 cases were effective at 6 months after treatment,8 cases were effective and 4 cases were ineffective,and the total effective rate was 92.0%.The Reffin,Reffex,VRin and VRex in the study group after 6 months treatment were significantly lower than those before treatment(P＜0.05).The IL-4,IL-10,histamine content before and 6 months after treatment in the study group were significantly higher than those in the control group,while the IL-2 and IFN-γ content in the study group were significantly lower than those in the control group,and the differences were statistically significant(P＜0.05).The IL-4,IL-10 and histamine content 6 months after treatment in the study group were significantly lower than those before treatment,and the differences were statistically significant(P＜0.05).There was no significant difference in the IL-2 and IFN-γ content 6 months after treatment in the study group compared with those before treatment(P＞0.05).Conclusion High intensity focused ultrasound in the treatment of allergic rhinitis can improve nasal mucosa responsiveness and hypersensitivity in patients with a better clinical effect.
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