Research progress on pharmacological activities of tetrandrine
GUO Min1,2 ZHANG Ru-yi2 CAI Fei2▲
1.Hubei University of science and technology Pharmacy College,Xianning City,Hubei Province,Xianning 437100,China;2.Hubei Key Laboratory of diabetes cardio cerebrovascular disease in Hubei Institute of science and technology,Xianning City,Hubei Province,Xianning 437100,China
Abstract:Tetrandrine (Tet)is extracted from the dry roots of tetrandrine.It belongs to isoquinoline alkaloids.In recent years,Tet is mainly used in clinical diseases,such as cardiovascular diseases,tumors and digestive diseases.Tet has potential value in clinic.This paper reviewes the pharmacological action of tetrandrine,aiming at better research and application of tetrandrine,guiding clinical medication and basic experimental research.
Liu KC,Lin YJ,Hsiao YT,et al.Tetrandrine induces apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells by endoplasmic reticulum stress and Ca2+/calpain pathways[J].Anticancer Res,2017,37(11):6107.
[2]
Imoto K,Takemura H ,Kwan CY,et al.Inhibitory effects of tetrand rine and hernandezine on Ca2+mobilization in rat glioma C6 cells[J].Res Commun Mol Path,1997,95(2):129-146.
[3]
Berridge MJ,Taylor CW.Inositol trisphosphate and calcium signaling[J].Ann Ny Acad Sci,2013,766(6410):583-589.
[4]
Gao LN,Feng QS,Zhang XF,et al.Tetrandrine suppresses articular inflammatory response by inhibiting pro-inflammatory factors via NF-κB inactivation[J].J Orthop Res,2016,34(9):1557.
[5]
Wang QS,Li X,Cui YL.The anti-Inflammatory effects of tetrandrine-loading poly (L-Lactic Acid)film in vitro[J].Adv Mater,2013,658:30-33.
Joshi P,Vishwakarma RA,Bharate SB.Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer[J].Eur J Med Chem,2017,138:273.
[10]
Yong Z,Ji-Wei MA,Liu HY,et al.Inhibitory effect of temozolomide combined with tetrandrine on human glioblastoma U87 cells[J].Pharmacol Toxicol,2014,28(3):367-372.
Yu J,Liu F,Sun M,et al.Enhancement of radiosensitivity and the potential mechanism on human esophageal carcinoma cells by tetrandrine[J].Cancer Biother Radiopharm,2011,26(4):437.
Liu MH,Xie WR,Zhang Z,et al.Inhibitive effect of tetrandrine on the proliferation of diabetes mellitus rats vascular smooth muscle cells[J].Zhong Yao Cai,2009,32(12):1867-1870.
Yang Q,Lv Z,Zhao Y,et al.Tetrandrine reduces infarct size and preserves cardiac function in rat myocardial ischemia/reperfusion injury through activation of Akt/GSK-3b signaling[J].Int J Clin Exp Med,2017,10(2):2541-2549.
[19]
Wu Z.Effect of tetrandrine on intracelluar Ca2+overload of cultured rat cardiomyocytes during hypoxia and reoxygenation[J].Clin Cardiol,2000,16(2):83-84
[22]
Jiang J,Zeng Q,Cao L.Effects of Tetrandrine on early after depolarizations and arrhythmias induced by Cesium Chloride in rabbits[J].J Catal,2002,(3):163-165.
[23]
Zhang J,Yu B,Zhang XQ,et al.Tetrandrine,an antihypertensive alkaloid,improves the sleep state of spontaneously hypertensive rats (SHRs)[J].J Ethnopharmacol,2014,151(1):729-732.