Application of hypersensitive C reactive protein in determination and prediction of severe infection in children with fever
ZHONG Xi-biao
Department of Pediatric Medicine,Family Planning Service Center for Maternal and Children′Health in Foshan City of Guangdong Province,Meizhou 514021,China
Abstract：Objective To analyze the effectiveness of application of hypersensitive C-reactive protein(hs-CRP)in determination and prediction of severe infection of children with fever.Methods 90 children with acute fever admitted to our hospital from November 2016 to November 2017 were selected as the study group.According to the infection situation,they were divided into severe infection group,local infection group and non-infection group,30 cases in each group,and 30 healthy children who underwent routine physical examination in our hospital during the same period were selected as the control group.All children were tested for hs-CRP by immunonephelometry,and the results were compared to evaluate the value of hs-CRP in the diagnosis and prediction of severe infection in children with acute fever.Results The level of hs-CRP in non-infected group was higher than that in control group (P＞0.05).The levels of hs-CRP in severe infection group and local infection group were significantly higher than those in control group (P＜0.05).The levels of hs-CRP in severe infection group and local infection group were significantly higher than those in non-infection group(P＜0.05).The level of hs-CRP in severe infection group was significantly higher than that in local infection group(P＜0.05).The hs-CRP levels of children in non-infection group,local infection group and severe infection group were significantly lower than those in control group(P＜0.05),and the hs-CRP levels of children in local infection group and severe infection group were significantly higher than those in control group(P＜0.05).The composition ratio of hs-CRP ＜ 10 mg/l in local infection group and severe infection group was significantly lower than that in non-infection group,and the composition ratio of 10-20 mg/l in local infection group was significantly higher than that in non-infection group and severe infection group.The composition ratio of＞20 mg/l in local infection group and severe infection group was significantly higher than that in non-infection group(P＜0.05).The hs-CRP levels of children in severe infection group were lower than those in local infection group (10 mg/l,10-20 mg/l),and those in severe infection group were higher than those in non-infection group and local infection group(P＜0.05).The positive rates of hs-CRP in four groups were statistically significant(P＜0.05).After treatment,the levels of hs-CRP in severe infection group,local infection group and non-infection group were significantly lower than those before treatment(P＜0.05).Conclusion hs-CRP plays a higher application value in determination and prediction of severe infection of children with fever prediction.With the aggravation of infection symptoms in children,the level of hs-CRP increases and the post-treatment hs-CRP level significantly decreases,suggesting that hs-CRP can be used as a reference index for determination and prediction of severe infection in emergency fever children.
钟喜标. 超敏C反应蛋白对儿童急诊发热患儿重症感染情况的判定及预测[J]. 中国当代医药, 2018, 25(10): 117-120.
ZHONG Xi-biao. Application of hypersensitive C reactive protein in determination and prediction of severe infection in children with fever. 中国当代医药, 2018, 25(10): 117-120.
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