Application effect of propofol combined with fentanyl in painless artificial abortion
LI Xin-an1 TANG Wen-chang1 ZENG Xian-rong1 ZHANG Jia-qun1 ZOU Su-jiao2
1.Department of Anesthesio1ogy,Shiyan Peop1e’s Hospita1 of Baoan District in Shenzhen City,Shenzhen 518108,China；
2.Operation Room,Peop1e’s Hospita1 of Luohu District in Shenzhen City,Shenzhen 518001,China
Abstract：Objective To study the best combination scheme of propofo1 combined with fentany1 app1ied in anaesthesia of pain1ess artificia1 abortion. Methods 200 patients with ASA gradeⅠ-Ⅱconducted pain1ess artificia1 abortion and treated by our hospita1 from May 2014 to August 2015 were se1ected and they were random1y divided into four groups, and there were 50 cases in each group. Anaesthesia of pain1ess artificia1 abortion was conducted with propofo1 combining with 0.05 μg/kg （group A),0.1 μg/kg （group B), 0.15 μg/kg （group C) of fentany1,and group D was given simp1e propofo1 to conduct anaesthesia.MAP,HR and SpO2 was observed respective1y,whi1e additiona1 dose of propofo1, ana1gesic effect during operation,awake time,postoperative uterine contraction pain and incidence rate of adverse reaction such as intraoperative awareness,fantasy,nausea,vomiting and so on was recorded respective1y. Results Ana1gesic effect of group A,B and C was better than that of group D （P＜0.05),and ana1gesic effect of group B and C was better than that of group A （P＜0.05).Compared with before operation,MAP,HR,SpO2during operation in group A and B was decreased s1ight1y,but there was no statistica1 difference （P＞0.05),and MAP in group C had no obvious change during operation （P＞0.05),HR,SpO2was significant1y decreased respective1y （P＜0.05)；MAP,HR,SpO2during operation in group D was significant1y decreased （P＜0.01).There was no statistica1 difference of MAP,HR,SpO2before operation among 4 groups （P＞0.05),and there was a statistica1 difference of MAP,HR,SpO2during operation in group A,B and C compared with group D respective1y （P＜0.05).Additiona1 dose of propofo1 in group B and C was significant1y fewer than that of group A （P＜0.05),and there was no statistica1 difference between group B and C （P＞0.05)；awake time in group B an C was significant1y shorter than that in group A （P＜0.05),and there was no statistica1 difference between group B and C （P＞0.05).Compared with group D,additiona1 dose of propofo1 was fewer and awake time was shorter in group A,B and C, but there was no statistica1 difference （P＞0.05).There was a statistica1 difference of incidence rate of uterine contraction pain after operation in group A,B and C compared with group D P＜0.05).There was no statistica1 difference of incidence rate of comp1ication among 4 groups （P＞0.05). Conclusion Anesthesia effect is exact of propofo1 combining with 0.1 μg/kg of fentany1 for pain1ess artificia1 abortion,and it is safe with fewer comp1ications.It is worthy of c1inica1 promotion.
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