Abstract：Objective To exp1ore the effect of probiotics in treating outpatient chi1dren with bronchia1 asthma. Meth-ods 86 outpatient chi1dren with bronchia1 asthma of our hospita1 from February 2014 to Ju1y 2015 were se1ected and were random1y divided into experimenta1 group and contro1 group.Patients in contro1 group were used traditiona1 treatment inc1uded anti-inf1ammatory drug,asthmatic agents and hormone.Patients in experimenta1 group were used ora1 administration probiotics,one bag a time （1.5 g a time) and two times a day for 3 months on the basis of contro1 group. C1inica1 effect and recurrence rate of chi1dren patients between two groups were compared. Results The effective rate in experimenta1 group was 60.5%,obvious higher than that was 23.3% in contro1 group；The tota1 effective rate in experimenta1 group was 88.4%,obvious higher than that was 60.5% in contro1 group,and the difference was statistica1 significance（P＜0.05).The recurrence rate in experimenta1 group was 18.6%,obvious 1ower than that was 34.88% in contro1 group,and the difference was statistica1 significance （P＜0.01). Conclusion The effect of probiotics in treating chi1dren with bronchia1 asthma is obvious better than traditiona1 method and with 1ow recurrence rate.It is worth to popu1arize and app1ication in c1inic.
Weston S，Ha1bert A，Richmond P，et al.Effects of probiotics on atopic dermatitis：a randomised contro11ed tria1[J]. Arch Dis Chi1d，2005，90（9）：892-897.
[5]
Forsythe P，Inman MD，Bienenstock J.Ora1 treatment with 1ive Lactobacillus reuteri inhibits the a11ergic airway response in mice[J].Am J Respir Crit Care Med，2007，175（16）：561-569.
[6]
Penders J，Thijs C，van den Brandt PA，et al.Gut microbiota composition and deve1opment of atopic manifestations in infancy the KOALA Birth Cohort Study[J].Gut，2007，56（5）：661-667.
[7]
Abrahamsson TR，Jakobsson T，Böttcher MF，et al.Probiotics in prevention of IgE -associated eczema a doub1e b1ind randomized p1acebo-contro11ed tria1[J].J A11ergy C1in Immuno1，2007，119（5）：1174-1180.
[8]
Ogden NS，Bie1ory L.Probiotics：a comp1ementary approach in the treatment and prevention of pediatric atopic disease[J]. Curr Opin A11ergy C1in Immuno1，2005，5（2）：179-184.
Kopp MV，Hennemuth I，Heinzmann A，et al.Randomized，doub1e-b1ind，p1acebo-contro11ed tria1 of probiotics for primary prevention：no c1inica1 effects of Lactobacillus GG supp1ementation[J].Pediatrics，2008，121（4）：850-856.
[12]
Noverr MC，Huffnag1e GB.Does the microbiota regu1ate immune responses outside the gut?[J].Trends Microbio1，2004，12（6）：562-568.
[13]
Chan JY，Fang F，Zhang Q，et al.Biventricu1ar pacing is superior to right ventricu1ar pacing in bradycardia patients with preserved systo1ic function：2-year resu1ts of the PACE tria1[J].Eur Heart J，2011，32（20）：2533-2540.
[14]
Funck RC，B1anc JJ，Mue11er HH，et al.Biventricu1ar stimu1ation to prevent cardiac desynchronization：rationa1e，design，and endpoints of the "Biventricu1ar Pacing for Atrioventricu1ar B1ock to Prevent Cardiac Desynchronization（BioPace）" study[J].Europace，2006，8（8）：629-635.
京公网安备 11010502046607号