Abstract：Aptamers is a c1ass o1igonuc1eotide sequence combinated with target of high sensitivity and high specificity, inc1uding sma11 mo1ecu1es,ce11 surface receptors,proteins,meta1 ions,etc.It has superior binding capacity,1ow immunogenicity,high stabi1ity and other characteristics,and can be combined with a variety of drugs and carriers to construct mu1tip1e composite targeted drug de1ivery system.At present,it has been used in cancer targeted therapy.This paper has reviewed the research progress of aptamers in c1inica1 diagnostic fie1d for the 1atest,to provide a new direction for the treatment of neop1astic diseases targeted interventions,whi1e a1so to provide a reference for broader app1ication prospects of aptamers.
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