Abstract：Objective To study the level and significance of plasma lipoprotein phospholipase A2（Lp-PLA2）in patients with cerebral infarction.Methods 120 patients with atherosclerotic cerebral infarction during January to December 2015 in neurology department of our hospital were selected into case group，and 120 healthy persons during the same period were randomly selected from medical examination center of our hospital into control group.Lp-PLA2，homocysteine（Hcy），low density lipoprotein cholesterol（LDL-C），fibrinogen（Fib），fasting blood glucose（Glu），and white blood cell （WBC）of the two groups were tested and compared.The subjects of cerebral infarction group were divided into mild，moderate and severe three groups，according to the severity of the disease（according to the National Institutes of Health Stroke Scale score）.The Lp-PLA2levels of the three groups were compared，and the correlations of Lp-PLA2with Hcy，LDL-C，Fib，Glu，and WBC were obtained according to the Spearman′s correlation analysis.Results The levels of Lp-PLA2，LDL-C，Hcy，Fib and WBC in the case group were higher than those in the control group respectively，with statistical significance （P＜0.05）.Lp-PLA2levels of the mild，moderate and severe groups of cerebral infarction were increased in turn，which were positively correlated with the severity of the disease，with statistical significance （P＜0.05）.The level of Lp-PLA2was positively correlated with LDL-C level，while it had no correlation with Hcy，Fib，Glu and WBC levels. Conclusion The level of Lp-PLA2reflects the severity of cerebral infarction，thus it can be used as a new method to predict the prognosis of cerebral infarction，and provide guidance information for clinical treatment decision.
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