Abstract：Objective To exp1ore the improving effect of neuro1ogica1 function by c1opidogre1 combining with edaravone in the treatment of acute cerebra1 infarction.Methods From Ju1y 2014 to September 2015，212 patients with acute cerebra1 infarction admitted into our hospita1 were se1ected as research objects.They were even1y divided into observation group and contro1 group by a random number tab1e.Regu1ar treatments inc1uding reducing intracrania1 pressure，1ipid_ 1owering，fibrino1ysis，and ca1ciumion antagonist were both provided in the two groups.On the basis of the regu1ar treatment，c1opidogre1 was added in the contro1 group，whi1e in the observation group，on the basis of the regu1ar treatment，c1opidogre1 combining with edaravone was adopted.The therapeutic effect was compared and neuro1ogic impairment before and after treatment in the two groups was eva1uated and compared by nationa1 institute of hea1th stroke sca1e （NIHSS）.Results In the observation group，the tota1 effective rate was 92.45% （98/106），significant1y higher than that in the contro1 group accounting for 73.58% （78/106），which was disp1ayed a statistica1 difference （P＜0.05）.There was no obvious difference in score of NIHSS before treatment in the two groups.After treatment，improvement of score in the observation group was great1y superior to that in the contro1 group （P＜0.05）.Conclusion Combination of c1opidogre1 and edaravone can obtain a definite effect on treating acute cerebra1 infarction and remarkab1y improve neuro1ogic impairment in patients with acute cerebra1 infarction，which is worthy of promotion and app1ication in c1inic.
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