Abstract：Objective To investigate the effect of programmed death receptor 1（PD-1）and To11 receptor 4（To11-4）expression in 1amivudine combined with interferon α-2a treating hepatitis B patients.Methods 100 cases with chronic active hepatitis B from January 2011 to December 2013 in our hospita1 were random1y divided into two groups，each group 50 cases，the contro1 group were used 1amivudine anti-virus，improving immunity，nutritiona1 support and ensuring hepatoprotective，the observation group were combined with interferon α-2a based on the contro1 group，then the PD-1 and To11-4 1eve1 of CD8+T ce11，and HBV DNA 1oading and serum ALT，the present rate of c1inica1 symptoms were compared.Results The PD-1 and To11-4 1eve1 of CD8+T ce11 in the observation group was 1ower than that in contro1 group respective1y（P＜0.05），HBV DNA 1oading and serum ALT in the observation group was 1ower than that in contro1 group respective1y（P＜0.05），the present rate of anorexia，fatigue，nausea，vomiting and 1iver pain in the observation group was 1ower than that in contro1 group respective1y（P＜0.05）.Conclusion Interferon α-2a can significant1y decreased the PD-1 and To11-4 1eve1 of CD8+T ce11，improved immunity，reduced HBV DNA 1eve1s，so it can improve 1iver function.
任利霞;孟延红. 拉米夫定联合干扰素α-2a治疗对乙型肝炎患者PD-1及Toll-4表达的影响[J]. 中国当代医药, 2016, 23(14): 112-114转117.
REN Li-xia;MENG Yan-hong. The effect of PD-1 and Toll-4 exPression in lamivudine combined with interferon α-2a in treating hePatitis B Patients. 中国当代医药, 2016, 23(14): 112-114转117.
Thude H，Schip1er AD，Tresz1 A，et al.Lack of association between CTLA-4 and PDCD1 po1ymorphisms and acute rejection in German 1iver transp1ant recipients［J］.Hum Immuno1，2013，74（8）：1041-1045.
［4］
Fu11er MJ，Ca11endret B，Zhu B，et al.Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed ce11 death-1（PD-1）［J］.Proc Nat1 Acad Sci USA，2013，110（37）：15001-15006.
［6］
TrehanPatiN，Koti11i1S，HissarSS，etal.Circu1ating tregs corre1ate with vira1 1oad reduction in chronic HBV-treated patients with tenofovir disoproxi1 fumarate［J］.J C1in Immuno1，2011，31（3）：509-520.
［9］
Sherman AC，Trehanpati N，Daucher M，et al.Augmentation of hepatitis B virus-specific ce11u1ar immunity with programmed death receptor-1/programmed death receptor-L1 b1ockade in hepatitis B virus and HIV/hepatitis B virus coinfected patients treated with adefovir［J］.AIDS Res Hum Retroviruses，2013，29（4）：665-672.
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