Abstract：Objective To discuss the related risk factors of pharyngeal fistula after hypopharyngeal carcinoma operation. Methods 43 patients with hypopharyngeal carcinoma treated in our hospital from May 2006 to December 2015 were selected.The related factors of pharyngeal fistula after operation including T stage，N stage，preoperative radiotherapy，preoperative tracheotomy，laryngeal function preservation，time duration of operation，flap repairing，and local infection were analyzed by Logistic analysis and single factor analysis.Results Pharyngeal fistula was observed in 9 patients of the 43 patients，and the incidence rate was 20.93%.The result of single factor analysis showed that the incidence of pharyngeal fistula was significantly higher in patients with preoperative radiotherapy，preoperative tracheotomy，laryngeal function resection，local infection，longer operation time，and flap repairing（P=0.0276，0.0096，0.0276，0.0296，0.0073，0.0113）；the incidence rate was significantly lower in patients at T1+T2 stages than in those at T3+T4 stages（P=0.0096）；and there was no significant difference between patients at N0+N1 stages and patients at N2+N3 stages （P=0.3826）.The result of Logistic analysis showed that T stage （OR＝5.376，P＝0.047）and local infection （OR＝16.651，P＝0.002）were independent risk factors of pharyngeal fistula after operation.Conclusion Based on assurance of therapeutic effect，risk factors should be prevented in preoperative preparation，operation process，and postoperative care.Measures should also be taken to manage risk factors and to further reduce the incidence of pharyngeal fistula after hypopharyngeal carcinoma operation.
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