Abstract：Objective To explore the application effect of problem-based learning combined with flipped classroom teaching mode in pathology teaching.Methods There were 201 students in the first grade nursing，that were selected and randomly divided into experiment group and control group.In addition，our study period was a total of 1 semester from March to June 2015.The experimental group were used the PBL combined with the Flipped classroom teaching method and control group were used traditional teachingmethod.Finally，The exam results of two groups and the degree of recognition on our teachingmethodswere analyzed.Results The experimental group（74.67±8.88）scores，was significantly higher than that of control group （69.49±11.45）scores at the end of the test results.Similarly，the experimental group students teaching evaluation was significantly higher than that of control group.The differences were all significant（P＜0.05）.Conclusion PBL combined with flipped classroom could sufficiently improve the self-study ability and the enthusiasm of the students.Moreover，our teaching quality could be significantly enhanced.
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