Abstract：Objective To observe the clinical effect of Atorvastatin combined with Trimetazidine in treatment of coronary heart disease（CHD）. Methods 180 caseswith CHD in the hospital from February 2015 to March 2016 were divided into Atorvastatin group（n=60），Trimetazidine group（n=60）and Atorvastatin combined with Trimetazidine comprehensive treatment group（n=60）according to different therapeuticmeasures，clinical efficacy among three groupswere compared.Results The total effective rate of comprehensive treatment group was 93.3%，significantly higher than 63.3%，68.3%of Atorvastatin group and Trimetazidine group respectively，and the difference was statistically significant（P＜0.05）；triacylglycerol（TG），total cholesterol（TC）and low density lipoprotein cholesterol（LDL-C）before treatment in three groups had no significant difference（P＞0.05）；after treatment，TG，TC and LDL-C in the comprehensive treatment group was lower than those of in the other 2 groups.Frequency of angina attack and duration of angina pectoris attack in the comprehensive treatmentgroup were less than those in the other 2 groups（P＜0.05）；the remission rate of adverse reaction in the comprehensive treatment group was significantly higher than that in the other 2 groups（P＜0.05）.Conclusion A-torvastatin combined with Trimetazidine in treatment of CHD hasmore ideal clinical curative effect，can improve the quality of life of patients and high safety，and it isworth popularization and application.
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