右美托咪定在小儿围术期的应用进展

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摘要右美托咪定是高选择性α2肾上腺素受体激动剂，具有镇静、镇痛、抗焦虑、抗交感、稳定血流动力学、减少麻醉用药量、呼吸抑制作用轻的特点。其在成人的临床应用价值得到越来越多的医师认同，但是小儿应用右美托咪定还未形成共识。本文就右美托咪定对小儿呼吸、循环的影响以及小儿应用右美托咪定的安全性等进行综述，旨在更好地指导右美托咪定在小儿麻醉中的应用。

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	彭旭桦
	姜闽英

关键词 ：右美托咪定, 麻醉, 围术期, 小儿

Abstract：Dexmedetomidine is a highly selective alpha 2-adrenoceptor agonist,which possesses the characteristics such assedation,analgesia,anti-anxiety,anti-sympathetic,hemodynamic stability,reducing dose ofanesthetic drugs,without causing respiratory depression.The value of the clinical application of Dexmedetomidine in adults is more and more recognized by doctors,but the application of Dexmedetomidine in children has not yet formed a consensus.In this article,the influence of Dexmedetomidine on respiration and circulation in children,and the safety of Dexmedetomidine in children were reviewed in order to better guide the application of Dexmedetomidine in pediatric anesthesia.

Key words： Dexmedetomidine Anesthesia Perioperative period Children

引用本文:

彭旭桦;姜闽英. 右美托咪定在小儿围术期的应用进展[J]. 中国当代医药, 2016, 23(31): 14-17.
PENG Xu-hua;JIANG Min-ying. Application progress of Dexmedetomidine in perioperative period of children. 中国当代医药, 2016, 23(31): 14-17.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2016/V23/I31/14

[1]	Mason KP，Lubisch NB，Robinson F，et al.Intramuscular dexmedetomidine sedation for pediatric MRI and CT[J].AJR Am J Roentgenol，2011，197（3）：720-725.
[2]	Aksu R，Kumandas S，Akin A，et al.The comparison of the effects of dexmedetomidine and midazolam sedation on elelctroencephalography in pediatric patients with febrile convulsion[J].Paediatr Anaesth，2011，21（4）：373-378.
[3]	Bergendahl H，Lonnqvist PA，Eksborg S.Clonidine：an alternative to benzodiazepines for premedication in children[J]. Curr Opin Anaesthesiol，2005，18（6）：608-613.
[4]	Yuen VM，Hui TW，Irwin MG，et al.A comparison of intranasal dexmedetomidine and oral midazolam for premedi-cation in pediatric anesthesia：a double-blinded randomized controlled trial[J].Anesth Analg，2008，106（6）：1715-1721.
[5]	TalonMD，WoodsonLC，SherwoodER，etal.Intranasal dexmedetomidine premedication is comparable with midazolam in burn children undergoing reconstructive surgery[J].J Burn Care Res，2009，30（4）：599-605.
[6]	Saadawy I，Boker A，Elshahawy MA，et al.Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics[J].Acta Anaesthesiol Scand，2009，53（2）：251-256.
[7]	Kohli U，Muszkat M，Sofowora GG，et al.Effects of variation in the human alpha-2A and alpha-2C adrenoceptor genes on cognitive tasks and pain perception[J].Eur J Pain，2010，14（2）：154-159.
[8]	Pestieau SR，QueZado ZM，Johnson YJ，et al.High-dose dexmedetomidine increases the opioid-free interval and decreases opioid requirement after tonsillectomy in children[J]. Can J Anaesth，2011，58（6）：540-550.
[9]	Olutoye O，Kim T，Giannoni C，et al.Dexmedetomidine as an analgesic for pediatric tonsillectomy and adenoidectomy[J]. Pediatr Anesth，2007，17（10）：1007-1008.
[10]	Yuen VM.Dexmedetomidine：perioperative applications in children[J].Pediatr Anesth，2010，20（3）：256-264.
[11]	Yildiz M，Tavlan A，Tuncer S，et al.Efect1of dexmedetomidine on haemodynamic responses to laryngoscopy and intubation：perioperative haemodynamics and anaesthetic requirements[J].Drugs Res Dev，2006，7（1）：43.
[12]	Tsai CJ.A comparison of the effectiveness of dexmedetomidine versus propofol target-controled infusion for sedation during fibreoptic nasotracheal intubation[J].Anaesthesia，2010，65（3）：254.
[13]	Guo H，Takahashi S.The effects of dexmedetomidine on left ventricular function during hypoxia and reoxygenation in isolated rat hearts[J].Anesth Aualg，2005，100（3）：629.
[14]	Snapir A，Posti J，Kentala E，et al.Efects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy male subjects[J]. Anesthesiology，2006，105（5）：902.
[15]	Wilder RT，Flick RP，Sprung J，et al.Early exposure to anesthesia and learning disabilities in a populationbased birth cohort[J].Anesthesiology，2009，110（4）：796-804.
[16]	Kakinohana M，Oshiro M，Saikawa S，et al.Intravenous infusion of dexmedetomidine can prevent the degeneration of spinal ventral neurons induced by intrathecal morphine after a noninjurious interval of spinal cordischemia in rats[J]. Anesth Analg，2007，105（4），1086-1093.
[17]	Turgut N，Turkmen A，Gokkaya S，et al.Dexmedetomidinebased versus fentanyl-based total intravenous anesthesia for lumbar laminectomy[J].Minerva Anestesiol，2008，74（9）：469.
[26]	Schulte-Uentrop L，Goepfert MS.Anaesthesia orsedation for MRI in children[J].Curr Opin Anaesthesiol，2010，23（4）：513-517.
[18]	Turgut N，Turkmen A，Ali A，et al.Remifentanil1-pmpofol vs demedetomidine anesthesia for surpatentorial craniotomy[J].Middle East J Anaesthesiol，2009，20（1）：63.
[19]	BekkerA，SturaitisM，BloomM，etal.Theeffectof dexmedetomidine on perioperative hemodynamics in patients undergoing craniotomy[J].Anesth Analg，2008，107（4）：1340.
[20]	Donfas AG，Lin CM，Suleman MI，et al.dexmedetomidine and meperidine additively reduce the shivering threshold in humans[J].Stroke，2003，34（5）：1218.
[21]	Mizrak A，Erbagci I，Arici T，et al.Dexmedetomidine use during strabismus surgery in agitated children[J].Med Princ Pract，2011，20（5）：427-432.
[22]	Ozcengiz D，Gunes Y，Ozmete O.Oral melatonin，dexmedetomidine，and midazolam for prevention of postoperative agitation in children[J].J Anesth，2011，25（2）：184-188.
[23]	Isik B，Arslan M，Tunga AD，et al.Dexmedetomidine decreases emergence agitation in pediatric patients after sevoflurane anesthesia without surgery[J].Pediatr Anesth，2006，16（7）：748-753.
[24]	SaadawyI，BokerA，ElshahawyMA，etal.Effectof dexmedetomidine on the charcteristics of bupivacaine in a caudal block in pediatrics[J].Acta Anaesthesiol Scand，2009，53（2）：251-256.
[25]	Sasaki T，Nemoto S，Ozawa H，et al.Planned sedation with dexmedetomidinehydrochlorideafterpediatriccardiac surgery;an institutional experience[J].Kyobu Geka，2009，62（2）：101-105.
[27]	Chrysostomou C，Komarlu R，Lichtenstein S，et al.Electrocardiographic effects of dexmedetomidine inpatients with congenital heart disease[J].Intensive Care Med，2010，36（5）：836-842.
[28]	Ray T，Tabias JD.Dexmedetomidine for sedation during electroencephal-ographic analysisin children with autism，pervasive developmental disorders，and seizure disorders[J]. J Clin Anesth，2008，20（5）：364-368.
[29]	Bernard PA，McCabe T，Bayliff S，et al.Successful treatment of ifosfamide neurotoxicity with dexmedetomidine[J].J Oncol Pharm Pract，2010，16（4）：262-265.
[30]	Oschman A，McCabe T，Kuhn RJ.Dexmedetomidine for opioid and benzodiazepine withdrawal in pediatric patients[J]. Am J Health Syst Pharm，2011，68（13）：1233-1238.
[31]	Parent BA，Munoz R，Shiderly D，et al.Use of dexmedetomidine in sustained ventyicular tachycardia[J].Anaesth Intensive Care，2010，38（4）：781.