酒精性肝硬化患者血清脂肪因子的临床意义分析

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摘要目的探讨酒精性肝硬化患者血清脂肪因子的临床意义。方法将2014年3月～2016年3月于河北省沧州市中心医院住院治疗的52例酒精性肝硬化患者作为肝硬化组，其中Child-Pugh分级A级17例，B级20例，C级15例；同时选择32名健康体检者作为对照组。检测并比较肝硬化组及不同Child-Pugh分级的肝硬化患者与对照组的血清网膜素、脂联素、内脏脂肪素及其他相关的临床生化参数；采用Spearman等级相关分析法及线性回归方程分析酒精性肝硬化患者血清脂肪因子与各生化指标的相关性。结果肝硬化组患者血清网膜素、脂联素水平分别为（925.19±167.58）ng/L和（908.06±156.96）μg/L，明显高于对照组[（793.68±100.38）ng/L、（649.97± 105.01）μg/L]（P<0.05）；肝硬化组患者内脏脂肪素水平为（18.61±3.75）μg/L，明显低于对照组[（23.39±6.15）μg/L]（P<0.05）；Child-Pugh分级A、B、C级肝硬化组患者间网膜素、脂联素、内脏脂肪素比较差异均无统计学意义（P> 0.05），而随着Child-Pugh分级A、B、C级的逐渐增高，肝硬化组患者的HOMA-IR和IL-6水平也逐渐升高（P< 0.05）。相关性分析结果显示，肝硬化组患者血清网膜素、脂联素、内脏脂肪素水平与胰岛素抵抗指数及胰岛素水平无明显相关性（P>0.05）。结论肝硬化时网膜素、脂联素升高，内脏脂肪素下降，其可作为预测肝硬化的指标，但不能作为肝功能严重程度的评估指标。

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	魏新亮
	魏思忱
	田树英
	孔郁
	王卫卫
	姜红玉

关键词 ：酒精性肝硬化, 网膜素, 脂联素, 内脏脂肪素, Child-Pugh分级, 胰岛素抵抗

Abstract：Objective To investigate the clinical significance of serum adipocyte factors in patients with alcoholic cirrhosis.Methods 52 patients with alcoholic cirrhosis from March 2014 to March 2016 in the Central Hospital of Cangzhou City were selected as liver cirrhosis group,among which 17 cases of class A of Child-Pugh grading,20 patients with class B,15 cases of grade C;and 32 healthy controls were selected as control group at the same time.Levels of serum omentin,adiponectin,visfatin and other related clinical and biochemical parameters were measured and compared between patients with liver cirrhosis,different Child-Pugh class of liver cirrhosis and control group.Spearman rank correlation analysis and equation of linear regression were used to analyzed the relationship between cirrhosis serum fat factors and the related biochemical indicators of patients with alcoholic liver.Results The levels of serum omentin and adiponectin in the liver cirrhosis group[(925.19±167.58)ng/L,(908.06±156.96)μg/L]were significantly higher than those of the control group[(793.68±100.38)ng/L,(649.97±105.01)μg/L](P<0.05),level of serum visfatin in the liver cirrhosis group[(18.61±3.75)μg/L]was significantly lower than that of the control group[(23.39±6.15)μg/L] (P<0.05).The levels of serum omentin,adiponectin,visfatin of patients with different Child-Pugh grading of liver cirrhosis had no statistically significant difference(P>0.05).As the increase of Child-Pugh grading,the levels of group of insulin resistance index and IL-6 increased gradually in patients of the liver cirrhosis group(P<0.05).Correlation analysis results show that,there was no significant correlation between the levels of adiponectin,omentin,visfatin and insulin resistance index in the liver cirrhosis group.Conclusion The levels of serum adiponectin,omentin evidently increase and the level of serum visfatin decrease in patients with alcoholic cirrhosis,and can be a prediction index of liver cirrhosis,but which can’t be use to evaluate the degree of liver cirrhosis.

Key words： Alcoholic cirrhosis Omentin Adiponectin Visfatin Child-Pugh grading Insulin resistance

基金资助:河北省沧州市科技计划项目（141302056）

引用本文:

魏新亮;魏思忱;田树英;孔郁;王卫卫;姜红玉. 酒精性肝硬化患者血清脂肪因子的临床意义分析[J]. 中国当代医药, 2016, 23(31): 18-20转42.
WEI Xin-liang;WEI Si-chen;TIAN Shu-ying;KONG Yu;WANG Wei-wei;JIANG Hong-yu. Analysis of clinical significance of serum adipocyte factors of patients with alcoholic cirrhosis. 中国当代医药, 2016, 23(31): 18-20转42.

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