替米沙坦对老年糖尿病合并高血压患者血清网膜素、白细胞介素-18水平的影响

摘要
图/表
参考文献(19)
相关文章 (15)

全文: PDF (0 KB) HTML (40 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨老年糖尿病（DM）合并高血压（HT）患者血清网膜素（Omentin）、白细胞介素-17（IL-17）、IL-18水平的变化及其在老年DM合并HT发病中的可能作用，探讨替米沙坦对老年DM合并HT患者血清Omentin、IL-17、IL-18水平的影响。方法选择2015年1月～2016年6月在我院治疗的老年2型DM患者126例，将其分为两组：合并HT老年2型DM患者72例﹙合并HT DM组﹚，血压正常老年2型DM患者54例﹙血压正常DM组﹚，选择同期我院体检健康老年人30例为正常对照组﹙对照组﹚。检测三组患者的血清Omentin、IL-17、IL-18水平，分析合并HT老年DM患者血清Omentin与IL-17、IL-18水平的关系及其在老年DM合并HT发病中的可能作用。观察替米沙坦治疗合并HT老年DM组治疗前后的血清Omentin、IL-17、IL-18水平的变化。结果合并HT DM组的血清Omentin水平较血压正常老年DM组降低，血清IL-17、IL-18水平较血压正常老年DM组升高，差异均有统计学意义（P＜0.01）。合并HT DM组的血清Omentin与IL-17、IL-18水平成明显负相关（r=-0.527，r=-0.602，P＜0.01）。合并HT老年DM组应用Telmisartan治疗后较治疗前血清Omentin水平升高，血清IL-17、IL-18水平降低，差异均有统计学意义（P＜0.01）。结论血清Omentin水平降低，IL-17、IL-18水平升高在老年DM合并HT的发病中发挥重要作用，替米沙坦治疗老年DM合并HT可升高血清Omentin水平，降低患者血清IL-17、IL-18水平。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	李兆雷
	岳伟
	王红
	孙薇
	崔秋子
	柴国禄

关键词 ： 2型糖尿病, 高血压, 网膜素, 白细胞介素-17, 白细胞介素-18

Abstract：ObjectiveTo study the changes of serum Omentin,IL-17 and IL-18 level,to studay the possible effect of of serum Omentin,IL-17 and IL-18 change in the develpment of hypertension,to investigate the effect of Telmisartan on the level of serum Omentin,IL-17 and IL-18 in the aged diabetic patients with hypertension.Methods126 aged patients with type 2 diabetes mellitus were selected from January 2015 to June 2016 in our hospital,and they were divided into two group:72 cases of type 2 aged diabetic patients with hypertension (diabetic patients with hypertension group) and 54 cases of type 2 aged diabetic patients with normal blood pressure (diabetic patients with normal blood pressure group).30 cases of normal aged individuals with physical examination during the same period were as the control group (control group).The level of serum Omentin,IL-17 and IL-18 were measured in the three groups.The relatoinshp between the serum Omentin level and serum IL-17,IL-18 level were analyzed in the aged diabetic patients with hypertension.The change of seroum Omentin,IL-17and IL-18 level were investigated in the aged diabetic patients with hypertension after treatment with Telmisartan.ResultsSerum Omentin level in the aged diabetic patients with hypertension group was significantly lower than those in the diabetic patients with normal blood pressure group,the serum IL-17 and IL-18 level in the aged diabetic patients with hypertension group were significantly higher than those in the aged diabetic patients with normal bloodpressure group,the differences were statistically significant(P＜0.01).A negtive correlation was found between serum Omentin level and serum IL-17,IL-18 level in the aged diabetic patients with hypertension group (r=-0.527,r=-0.602, P＜0.01).Serum Omentin level was significantly increased,the levels of IL-17 and IL-18 were significantly decreased after treatment with Telmisartan in the aged diabetic patients with hypertension group,the differences were statistically significant(P＜0.01).ConclusionThe low serum level of Omentin and increased serum level of IL-17,IL-18 might play an important role in the development of hypertension in the aged diabetic patients.The serum Omentin level was significantly increased,the level of IL-17 and IL-18 were significantly decreased after treatment with Telmisartan in the aged diabetic patients with hypertension.

Key words： Type 2 diabetic patient Hypertension Omentin IL-17 IL-18

作者简介: 李兆雷（1982-），男，汉族，主治医师，研究方向：糖尿病慢性合并症的发病机制及防治

引用本文:

李兆雷；岳伟；王红；孙薇；崔秋子；柴国禄. 替米沙坦对老年糖尿病合并高血压患者血清网膜素、白细胞介素-18水平的影响[J]. 中国当代医药, 2017, 24(14): 52-55.
LI Zhao-lei；YUE Wei；WANG Hong；SUN Wei；CUI Qiu-zi；CHAI Guo-lu. Effect of Telmisartan on the level of serum Omentin and IL-18 in the aged diabetic patients with hypertesion. 中国当代医药, 2017, 24(14): 52-55.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2017/V24/I14/52

[1]	李晶，马宇虹，程文俊.脂联素、同型半胱氨酸和超敏C反应蛋白与高血压的关系[J].中国当代医药，2016，23（28）：44-46.
[2]	王明毅，张宇静，徐建，等.替米沙坦对冠心病合并轻度高血压患者颈动脉内膜中层厚度及炎症因子的影响[J].中国当代医药，2014，21（35）：71-73.
[3]	Liu R，Wang X，Bu P.Omentin-1 is associated with atherosclerosis in patients with metabolic syndrome[J].Diabet Res Clin Pract，2014，11（20）：72-74.
[4]	胡海洋，王瑞英，李宇新，等.高血压合并肥胖患者血清网膜素-1水平及其与动脉弹性的相关性[J].中华高血压杂志，2015，28（2）：146-149.
[5]	Moreno-Navarrete JM，Ortega F，Castro A，et al.Circulating Omentin as a novel biomarker of endothelical dysfunction[J]. Obesity（Silver Spring），2011，19（8）：1552-1559.
[6]	金鹏，李伟，李涛，等.高血压患者血清肝细胞生长因子的表达及与血管内皮功能的关系[J].中国当代医药，2016，23（30）：143-145.
[7]	Akbarzadeh S，Ghasemi S，Kalantarhormozi M，et al.Relationship among plasma adipokines，insulin and androgens level as well as biochemical glycemic and lipidemic markers with normal BMI[J].Gynecol Endocrinol，2012，28（7）：521-524.
[8]	童玉帆.李顺辉，刘丽赟，等.頡沙坦＋饮食控制对高血压合并糖耐减低患者胰岛素抵抗的影响[J].中国当代医药，2016，23（13）：138-140.
[13]	阳慧，苏雨江，陆士娟，等.血浆IL-17水平与颈动脉内中膜厚度的相关性[J].海南医学，2014，25（8）：1105-1110.
[15]	李凡，谢静，英明中，等.血管紧张素Ⅱ和坎地沙坦对小鼠骨骼肌细胞C2C12胰岛素敏感性的影响[J].中国医药导报，2015，12（7）：14-18.
[16]	杨裕华，贺法宪，王际莘.网膜素研究进展[J].中国老年学杂志，2012，32（8）：3335-3338.
[17]	李红微，刘胜阳，刘云霞，等.替米沙坦治疗早期糖尿病肾病的效果观察[J].中国当代医药，2016，23（4）：73-75.
[9]	Kazama K，Okada M，Yamawaki H，et al.A novel adipocytokiine omentin，inhibits palatelet-deerived growth factor-BB-induced vascular smooth muscle cell migration through antioxdative mechnism[J].Am J Phsiol Heart care physiol[J]. 2014，306（12）：H1714-H1719.
[10]	Yamawaki H，Kuramoto J，Kameshima S，et al.Omentin，a novel adipocylokine inhibits TNF-α-induced inflammation in human endothelial cells[J].Biochem Biophys Res Commun，2011，408（2）：339-343.
[11]	Kazama K，Usui T，Okada M，et al.Omentin plays an antiinflammatory role through inhibition of TNF-α- induced superoxide production in vascular smooth muscle cells[J]. Eur J Pharmacol，2012，686（1-3）：116-123.
[12]	Pietrowski E，Bender B，Huppert J，et al.Pro-inflammatory effects of interleukin-17A onvascular smooth muscle cells involve NAD （P）H-oxidase derived reactive oxygen species[J].J Vase Res，2011，48（1）：52-58.
[14]	Krishhhnan SM，Sobey CG，Latz E，et al.IL-1β and IL-18 inflammatory markers or mediators of hypertension？[J].Br J Pharmacol，2014，171（24）：5589-5602.
[18]	Fang F，Liu GC，Kim C，et al.Adiponectin attenuates angiotensinⅡ-induced oxidative stress in renal tubular cells through AMPK and cAMP-Epac signal transductionpathways[J].Am J Physiol Reeeenal Physiol[J].2013，304 （11）：1366-1374.
[19]	Tan BK，Adya R，Farhatullah S，et al.Metformin treatinent may increase omention-l levels in women with polycystic ovary syndrome[J].Diabetes，2010，59（2）：3023-3031.