Abstract:Objective To explore the occurrence regularity and characteristics of adverse drug reaction(ADR)in children,and to provide guidance for clinicalmedication.M ethods The report of 130 cases of pediatric ADR collected in our hospital from July 2015 to July 2016 were selected,different types of drug,drug administration and clinicalmanifestations of ADR were compared and analyzed.Results In terms of gender and age,constituent ratio of women was 52.31%,little higher than 47.69%ofmen,the highest proportion of the age group was 1-3 years old(36.92%).In term of drug types,the highest proportion was antibiotic(38.63%),which was followed by traditional Chinesemedicine(25.00%). Thehighestpercentageof ADR resulted from antibiotics(48.46%),and the second highestwas traditionalChinesemedicine (32.31%).In terms of drug administration,the highest percentage of ADR resulted from intravenous injection(70.00%).In termsof clinicalmanifestation,the incidence of digestive system injurywas the highest(41.53%).Conclusion The strengthening of the prevention work,rational use of drugs and safemedication can decrease the occurrence of ADR.
穆菁. 130例小儿药物不良反应分析及用药指导[J]. 中国当代医药, 2016, 23(32): 150-152.
MU Jing. Analysis of 130 cases w ith adverse drug reactions in children and the guidance of drug use. 中国当代医药, 2016, 23(32): 150-152.
Eriksson R,Aagaard L,Jensen LJ,et al.Discrepancies in listed adverse drug reactions in pharmaceuticalproduct information supplied by the regulatory authorities in Denmark and the USA[J].Pharmacol Res Perspect,2014,2(3):e00038.
Agundez JA,EsguevillasG,Amo G,etal.Pharmacogenomics testing for type B adverse drug reactions to anti-infective drugs:the example of hypersensitivity to abacavir[J].Recent Pat Antiinfect Drug Discov,2014,9(2):151.