Abstract：ObjectiveTo investigate the effect of pepsinogen (PG)and gastrin-17 (G-17)combined with endoscopic screening in the diagnosis of early gastric cancer.MethodsFrom January 2015 to December 2015,145 outpatient and inpatient 145 subjects because of upper abdominal pain,belching and other symptoms of upper digestive tract in our hospital were selected and divided into the normal group(n=30),the atrophic gastritis group(n=28),the gastric ulcer group (n=25),the early gastric cancer group (n=32)and the advanced gastric cancer group (n=30)according to endoscopic biopsy and histopathological examination.The levels of serum PGⅠ,PGⅡand G-17 were detected,and their value in the diagnosis of gastric cancer was discussed.ResultsThe levels of PGⅠand PGR in the atrophic gastritis group,the early gastric cancer group and the advanced gastric cancer group was lower than that in the normal group,the G-17 level was higher than in the normal group(P＜0.05).The levels of PGⅠand PGR in the atrophic gastritis group and the gastric ulcer group was higher than that in the early gastric cancer group,the levels of PGⅠand PGR in the advanced gastric cancer group was lower than that in the early gastric cancer group,the level of G-17 in the advanced gastric cancer group was higher than that in the early gastric cancer group (P＜0.05).The AUC of PGⅠ,PGⅡ,PGR,G-17 and joint detection in the gastric cancer group and the non-gastric cancer group was significantly higher than that in the control group(AUC= 0.5)(P＜0.05).Four groups of joint detection of AUC was higher than that in the single detection,the specificity and sensitivity of joint detection was higher than that in the non-gastric cancer group.ConclusionThe PGⅠ,G-17 combined with endoscopic screening is help to improve the early diagnosis rate of gastric cancer,it is worthy of clinical promotion and application.
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