GLI1与胃癌上皮间质转换的关系及临床研究

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摘要目的观察GLI1表达与胃癌上皮间质转换的关系。方法收集2006年1月～2011年12月诊断明确、资料完整的58例手术切除胃癌标本，做成组织芯片，采用免疫组化SP的方法检测组织芯片中胃癌组织及正常胃黏膜组织中GLI1、E-cadherin、N-cadherin的表达。结果GLI1在胃癌中表达较正常组织高，与胃癌的淋巴转移、临床分期、Lauren分型、肿瘤分化明显有关，差异有统计学意义（P＜0.05）；E-cadherin在正常胃黏膜组织表达比胃癌组织高，与胃癌的淋巴转移、临床分期、Lauren分型、肿瘤分化明显有关，差异有统计学意义（P＜0.05）；N-cadherin在胃癌中表达高于正常胃黏膜组织，与胃癌的淋巴转移、临床分期、Lauren分型、肿瘤分化明显有关，差异有统计学意义（P＜0.05）；GLI1表达与上皮间质转换的状态有关，差异有统计学意义（P＜0.01）。结论在胃癌组织中GLI1表达与E-cadherin、N-cadherin有关，提示GLI1可能参与了EMT过程。

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	林智平
	段炤

关键词 ：胃癌, GLI1, 上皮间质转换

Abstract：ObjectiveTo observe the relationship between GLI1 expression and epithelial-mesenchymal transition in gastric cancer.Methods58 cases of gastric cancer specimens who were given surgical resection with clear diagnosis and complete data from January 2006 to December 2011 were collected,and tissue microarray was made.The expression of GLI1,E-cadherin and N-cadherin in gastric carcinoma and normal gastric mucosa in tissue microarray were detected by immunohistochemical SP method.ResultsGLI1 expression in gastric cancer was higher than that in normal tissues(P＜0.05),which was significantly associated with lymph node metastasis,clinical staging,Lauren typing and tumor differentiation of gastric cancer,with significant difference(P＜0.05).The expression of E-cadherin in normal gastric mucosa was higher than that in gastric cancer(P＜0.05),which was significantly associated with lymph node metastasis,clinical staging,Lauren typing and tumor differentiation of gastric cancer,with significant difference(P＜0.05).The expression of N-cadherin in gastric cancer was higher than that in normal gastric mucosa(P＜0.05),which was significantly associated with lymph node metastasis,clinical staging,Lauren typing and tumor differentiation of gastric cancer,with significant difference(P＜0.05).GLI1 expression was associated with epithelial-mesenchymal transition,with significant difference(P＜0.01).ConclusionThe expression of GLI1 in gastric cancer is associated with E-cadherin and N-cadherin,indicating that GLI1 may be involved in the EMT process.

Key words： Gastric cancer GLI1 Epithelia-mesenchymal transition

引用本文:

林智平；段炤. GLI1与胃癌上皮间质转换的关系及临床研究[J]. 中国当代医药, 2017, 24(29): 49-52.
LIN Zhi-ping；DUAN Zhao. Relationship between GLI1 and epithelial-mesenchymal transition in gastric cancer and its clinical study. 中国当代医药, 2017, 24(29): 49-52.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2017/V24/I29/49

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