Abstract：Objective To explore the effect and safety of fractional CO2 laser combined with Tacrolimus Ointment on vitiligo.Methods A total of 60 patients with vitiligo admitted to Hongqi Hospital Affiliated Mudanjiang Medical University from June 2018 to October 2019 were selected as the research objects and divided into the treatment group and the control group according to the random number table method,with 30 cases in each group.The control group was treated with Tacrolimus Ointment,and the treatment group was treated combined with fractional CO2 laser based on the control group.After 12 weeks of treatment,both skin lesions and adverse reactions were observed between the two groups.Results The total efficiency of the treatment group(66.7%)was higher than that of the control group(36.7%),the total skin lesions efficiency of the treatment group(76.2%)was higher than that of the control group(42.1%),the differences were statistically significant(P<0.05).There were no serious adverse reactions were observed in both groups.Conclusion Fractional CO2 laser combined with Tacrolimus Ointment has a good clinical effect in vitiligo therapy and had no serious adverse reactions.
Chiu YJ，Perng CK，Ma H.Fractional CO2laser contributes to the treatment of non-segmental vitiligo as an adjunct therapy：a systemic review and meta-analysis[J].Lasers Med Sci，2018，33（7）：1549-1556.
Daniel BS，Wittal R.Vitiligo treatment update[J].Australas J Dermatol，2015，56（2）：85-92.
[12]
Sklar LR，Burnett CT，Waibel JS，et al.Laser assisted drug delivery：A review of an evolving technology[J].Lasers Surg Med，2014，46（4）：249-262.
[13]
Hu Y，Qi X，Hu Y，et al.Effects of CO2fractional laser therapy on peripheral blood cytokines in patients with vitiligo[J].Dermatol Ther，2019，32（4）：e12992.
[14]
Hélou J，Maatouk I，Obeid G，et al.Fractional laser for vitiligo treated by 10 600 nm ablative fractional carbon dioxide laser followed by sun exposure[J].Lasers Surg Med，2014，46（6）：443-448.
[15]
Ross EV，Yashar SS，Naseef GS，et al.A Pilot Study of In Vivo Immediate Tissue Contraction with CO2Skin Laser Resurfacing in a Live Farm Pig[J].Dermatol Surg，2010，25（11）：851-856.
[1]
Wang Y，Li S，Li C.Perspectives of New Advances in the Pathogenesis of Vitiligo：From Oxidative Stress to Autoimmunity[J].Med Sci Monit，2019，6（25）：1017-1023.
[2]
Liu L，Li C，Gao J，et al.Genetic polymorphisms of glutathione S-transferase and risk of vitiligo in the Chinese population[J].J Invest Dermatol，2009，129（11）：2646-2652.
[16]
Chen W，Zhou Y，Huang FR，et al.Preliminary study on the treatment of vitiligo with carbon dioxide fractional laser together with tacrolimus[J].Lasers Surg Med，2018，50（8）：829-836.
[17]
Esme P，Gür Aksoy G，Elcin G.No Additional Benefit of Combining Fractional Carbon Dioxide Laser With Narrow-Band Ultraviolet B Phototherapy for Vitiligo：A Randomized Prospective Study With Half-Body Side Comparison[J].Dermatol Surg，2019，45（12）：1627-1634.
[18]
Chang HC，Lin MH，Tsai HH.Efficacy of Combination Therapy With Fractional Carbon Dioxide Laser and Ultraviolet B Phototherapy for Vitiligo：A Systematic Review and Meta-Analysis[J].Aesthet Surg J，2020，40（1）：46-50.
[19]
Kim HJ，Hong ES，Cho SH，et al.Fractional Carbon Dioxide Laser as an "Add-on" Treatment for Vitiligo：A Metaanalysis with Systematic Review[J].Acta Derm Venereol，2018，98（2）：180-184.
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