Clinical effect of subcutaneous buried vertical pad tension reduction suture combined with 90Sr-90Y application in the treatment of keloid after operation
MA Hong-yan SUN Yi-feng YANG Xiao-juan WANG Yan-qing MENG Xiang-hui▲
Department of Dermatology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Heilongjiang Province, Mudanjiang 157000, China
Abstract:Objective To investigate the clinical effect of subcutaneous buried vertical pad tension reduction suture combined with 90Sr-90Y application after operation. Methods A total of 100 cases of keloid treated in Hongqi Hospital Affiliated to Mudanjiang Medical University from August 2018 to February 2020 were selected as the research subjects. They were divided into observation group (58 cases) and control group (42 cases) according to the method of coin tossing. The observation group was treated with subcutaneous buried vertical bedding compression suture combined with 90Sr-90Y application, the control group was treated with 90Sr-90Y application, and the curative effect and Vancouver scar scale (VSS) score were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After 1 year of treatment, the VSS score of the observation group was lower than that of the control group, and the difference was statistically significant (P<0.05). Conclusion Postoperative subcutaneous burying vertical pad compression suture combined with 90Sr-90Y application is a simple treatment, short treatment period, good efficacy, less side effects, suitable for clinical promotion.
马红燕;孙一峰;杨小娟;王燕清;孟祥慧. 术后皮下埋没垂直褥式减张缝合联合90Sr-90Y敷贴治疗瘢痕疙瘩的临床效果[J]. 中国当代医药, 2021, 28(28): 36-39.
MA Hong-yan;SUN Yi-feng;YANG Xiao-juan;WANG Yan-qing;MENG Xiang-hui. Clinical effect of subcutaneous buried vertical pad tension reduction suture combined with 90Sr-90Y application in the treatment of keloid after operation. 中国当代医药, 2021, 28(28): 36-39.
Jfri A,O'brien E,Alavi A,et al.Association of hidradenitis suppurativa and keloid formation:a therapeutic challenge[J].JAAD Case Rep,2019,5(8):675-678.
[8]
Nangole FW,Agak GW.Keloid pathophysiology:fibroblast or inflammatory disorders?[J].JPRAS Open,2019,22:44-54.
Liu Y,Ren L,Liu W,et al.MiR-21 regulates the apoptosis of keloid fibroblasts by caspase-8 and the mitochondriamediated apoptotic signaling pathway via targeting FasL[J].Biochem Cell Biol,2018,96(5):548-555.
[11]
Yang X,Shao Y,Yu W,et al.A novel radiotherapy approach for keloids with intrabeam[J].Biomed Res Int,2019,2019:4693528.
[12]
Khare N,Patil SB.A novel approach for management of ear keloids:results of excision combined with 5-fluorouracil injection[J].J Plast Reconstr Aesthet Surg,2012,65(11):e315-e317.
[13]
Lee SY,Kim EK,Seo HB,et al.IL-17 Induced Stromal Cell-Derived Factor-1 and Profibrotic Factor in Keloid-Derived Skin Fibroblasts via the STAT3 Pathway[J].Inflammation,2020,43(2):664-672.
[14]
Harn IC,Ogawar,Hsu CK,et al.The Tension Biology of Wound Healing[J].Exp Dermatol,2019,28(4):464-471.
Veen RE,Kal HB,Postoperative high-dose-rate brachytherapy in the prevention of keloids[J].Int J Radiat Oncol Biol Phys,2007,69(4):1205-1208.
[17]
Liu S,Liang W,Song K,et al.Keloid skin flap retention and resurfacing in facial keloid treatment[J].Aeshetic Plast Surg,2018,42(1):304-309.
[18]
Ogawa R,Tosa M,Dohi T,et al.Surgical excision and postoperative radiotherapy for keloids[J].Scars Burn Heal,2019,5:2059513119891113.
[19]
Lu F,Ogawa R,Nguyen DT,et al.Microdeformation of three-dimensional cultured fibroblasts induces gene expression and morphological changes[J].Ann Plast Surg,2011,66(3):296-300.
[20]
Hirohi T,Yoshimura K.Lower face reduction with fullthickness marginal ostectomy of mandibular corpus-angle followed by corticectomy[J].J Plast Reconstr Aesthet Surg,2010,63(8):1251-1259.