Abstract：Objective To investigate the application effect of bi-level non-invasive ventilation therapy in chronic obstructive pulmonary disease combined with obstructive sleep apnea hypopnea syndrome. Methods A total of 62 COPD patients with OSAHS who were admitted to Yunfu City People′s Hospital from June 2020 to June 2021 were selected as the research objects，and they were divided into the control group and the study group using the random number table method，with 31 cases in each group. The control group was treated with oxygen therapy，and the study group was treated with bi-level positive airway pressure. The arterial partial pressure of oxygen (PaO2)，arterial partial pressure of carbon dioxide (PaCO2)，oxygen saturation (SaO2)，apnea-hypopnea index (AHI)，and longest apnea time (LAT)，mean blood oxygen saturation at night (M-SaO2)，minimum blood oxygen saturation at night (L-SaO2) before treatment and 7 days after treatment，total clinical effective rate and adverse reactions were compared between the two groups. Results There was no significant difference in PaO2，PaCO2，SaO2，AHI，LAT，M-SaO2，L-SaO2 between the two groups before treatment (P＞0.05). After treatment，the PaO2，SaO2，M-SaO2，and L-SaO2 of the two groups were higher than those of the group before treatment，and the PaO2，SaO2，M-SaO2，and L-SaO2 of the study group were all higher than those of the control group，and the differences were statistically significant. (P＜0.05). After treatment，the PaCO2 and AHI of the two groups were lower than before the treatment，and the PaCO2 and AHI of the study group were lower than those of the control group，the differences were statistically significant (P＜0.05). After treatment，the LAT of the study group was shorter than that of this group before treatment and the control group，the differences were statistically significant (P＜0.05). The total clinical effective rate of the study group was higher than that of the control group，and the difference was statistically significant (P＜0.05). There were no obvious adverse reactions in the two groups. Conclusion The application effect of bi-level non-invasive ventilation in the treatment of COPD combined with OSAHS is relatively good. It can improve hypoxia，relieve hypercapnia，improve sleep quality，safety，and comprehensive application value.
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