Abstract：Objective To explore the clinical effect of Tongqiao Biyan Tablets combined with Pidotimod Oral Liquid in the treatment of allergic rhinitis in children.Methods A total of 84 children with allergic rhinitis admitted in the Second People′s Hospital of Yichun City from January 2020 to September 2020 were selected as the research subjects,and they were divided into the control group(42 cases)and the study group(42 cases)by random number table method.The control group was treated with Pidotimod Oral Liquid,and the study group was treated with Tongqiao Biyan Tablets combined with Pidotimod Oral Liquid.The clinical effect,levels of inflammatory cytokine,clinical symptom scores and adverse reactions were compared between the two groups.Results The total effective rate in the study group was 92.86%,which was higher than that in the control group(76.19%),and the difference was statistically significant(P＜0.05).Before treatment,there were no significant differences in the levels of interleukin-5(IL-5)and tumor necrosis factor-α(TNF-α)between the two groups(P＞0.05).After treatment,the levels of IL-5 and TNF-α in the study group were(10.21±0.87)pg/ml and(26.29±3.67)mg/ml,respectively,which were lower than those in the control group of(12.36±1.26)pg/ml and(36.51±4.64)mg/ml,with statistical significances(P＜0.05).Before treatment,there were no significant differences in sneeze frequency score,nasal overflow score,nasal obstruction score and the total score between the two groups(P＞0.05).After treatment,the sneeze frequency score,nasal overflow score,nasal congestion score and total score of the study group were(0.92±0.08),(1.12±0.11),(1.04±0.13),(3.08±0.32)points,respectively,which were lower than those in the control group of(1.36±0.18),(1.64±0.21),(1.67±0.24)and(4.67±0.63)points,with statistical significances(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Tongqiao Biyan Tablets combined with Pidotimod Oral Liquid can effectively relieve the clinical symptoms of allergic rhinitis in children,reduce the level of inflammatory cytokin,and has obvious effect and high application value.
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