低频超声治疗化疗性静脉炎的实验研究

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摘要目的探讨低频超声治疗化疗性静脉炎的效果及对炎症指标的影响，为化疗性静脉炎治疗的机制研究提供实验基础。方法选取40 只SD 雄性大鼠，按照随机数字表法分为空白对照组、模型组、喜辽妥治疗组、低频超声治疗组，每组各10 只。除空白对照组外，其余三组均通过尾静脉注射长春瑞滨，建立化疗性静脉炎模型。空白对照组、模型组不予治疗处理，喜辽妥治疗组连续3 d 涂抹喜辽妥，低频超声治疗组连续3 d 进行低频超声辐照，每次30 min。观察大鼠尾静脉注射部位局部外观和病理形态学改变，检测大鼠外周血血清中肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）的含量。结果与空白对照组比较，模型组静脉炎症明显，模型组的TNF-α 水平高于空白对照组，IL-6 水平低于空白对照组，差异有统计学意义（P＜0.05）。与模型组比较，喜辽妥治疗组和低频超声治疗组的静脉炎症缓解，两组的TNF-α 水平低于模型组，IL-6 水平高于模型组，差异有统计学意义（P＜0.05）。喜辽妥治疗组和低频超声治疗组的TNF-α、IL-6 水平比较，差异无统计学意义（P＞0.05）。结论低频超声通过下调TNF-α 水平、提高IL-6 水平缓解了化疗性静脉炎的损伤。

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关键词 ：化疗性静脉炎, 低频超声, 喜辽妥, 炎症

Abstract：Objective To explore the effect of low-frequency ultrasound in the treatment of chemotherapy-induced phlebitis and its influence on inflammatory indexes, so as to provide experimental basis for the mechanism research of chemotherapy phlebitis. Methods A total of 40 male SD rats were selected and divided into the blank control group,the model group, the Hirudoid Cream treatment group and the low-frequency ultrasound treatment group according to the random number table method, 10 rats in each group. Except for the blank control group, the last 3 groups were all injected with Vinorelbine through tail vein to establish an animal model of chemotherapy-induced phlebitis. The blank control group and the model group were not treated. The Hirudoid Cream treatment group was treated for 3 consecutive days by Hirudoid Cream. The Low-frequency ultrasound treatment group was treated for 3 consecutive days by lowfrequency ultrasound, 30 min each time. The changes of local appearance and pathomorphology of the injection site of tail vein were observed, and the levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in peripheral blood serum were detected. Results Compared with the blank control group, the model group showed obvious venous inflammation. The levels of TNF-α in the model group was higher than that in the blank control group, while the level of IL-6 in the model group was lower than that in the blank control group (P＜0.05). Compared with the model group,the Hirudoid Cream treatment group and the low-frequency ultrasound treatment group showed a significant improvement in inflammation. The levels of TNF-α in the both treatment group were lower than those in the model group,while the serum levels of IL-6 in the both treatment group were higher than those in the model group (P＜0.05). There were no significant differences in the levels of TNF-α and IL-6 between the Hirudoid Cream treatment group and the low-frequency ultrasound treatment group (P＞0.05). Conclusion Low-frequency ultrasound alleviates the damage of chemotherapy-induced phlebitis by down regulating the level of TNF-α and increasing the level of IL-6.

Key words： Chemotherapy-induced phlebitis Low frequency ultrasound Hirudoid Cream Inflammation

收稿日期: 2020-10-14

基金资助:广东省医学科学技术研究基金项目（B2019136）

引用本文:

温棉棉；尚瑶瑶；王奕. 低频超声治疗化疗性静脉炎的实验研究[J]. 中国当代医药, 2021, 28(12): 59-061.
WEN Mian-mian1 SHANG Yao-yao1 WANG Yi2▲. Experimental study of low frequency ultrasound in the treatment of chemotherapy-induced phlebitis. 中国当代医药, 2021, 28(12): 59-061.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2021/V28/I12/59

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