Abstract：Objective To investigate the expression changes and clinical significance of signal transducer and activator of transcription 3 (STAT3) and epidermal growth factor receptor (EGFR) in patients with cervical intraepithelial neoplasia (CIN). Methods The clinical data of 260 patients with CIN admitted to Liaoyang Central Hospital from December 2018 to December 2019 were retrospectively collected. According to the cervical lesions, they were divided into the CIN class Ⅰgroup (mild atypical hyperplasia, 102 cases), the CIN class Ⅱgroup (moderate atypical hyperplasia, 89 cases) and the CIN class Ⅲgroup (severe atypical hyperplasia and carcinoma in situ, 69 cases). The expression levels of STAT3 and EGFR were compared among the three groups, and the ROC curve was drawn to analyze the value of STAT3 and EGFR expression and their combined detection in the diagnosis of CIN. Results Western blot analysis showed that the expression levels of STAT3 and EGFR in the CIN class Ⅲgroup were higher than those in the CIN class Ⅱgroup and the CIN class Ⅰgroup and the differences were statistically significant (P＜0.05). AUC of STAT3 and EGFR in diagnosing CIN was 0.807 and 0.835 respectively, which had certain diagnostic value. The AUC of combined detection was 0.903, and the specificity and sensitivity of combined detection were higher than those of single detection, which indicated that the diagnostic performance of combined detection was high. Conclusion The expression levels of STAT3 and EGFR are all related to the degree of cervical intraepithelial neoplasia. Combined detection of their levels has high diagnostic value and can be used for early prediction of clinical cervical cancer.
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