中老年2型糖尿病患者视网膜病变的影响因素分析

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摘要目的探讨中老年2 型糖尿病患者糖尿病性视网膜病变（DR）的影响因素。方法选取2018年1月～2019年12月于葫芦岛市中心医院收治的460 例中老年2 型糖尿病患者作为研究对象。对其进行病史采集、体格检查，抽取空腹静脉血检测生化指标，由专业眼科医师进行眼底检查，根据眼底情况分为正常眼底（NDR）组（295 例）及糖尿病性视网膜病变（DR）组（165 例）。总结葫芦岛市中心医院收治的中老年2 型糖尿病患者视网膜病变的患病率。采用Logistic 回归模型分析DR 与各影响因素的相关性。结果 DR 患者患病率35.9%，其中病程＜5年、5～10年、＞10年DR 患病率分别为18.1%、31.6%、53.8%，差异有统计学意义（P＜0.05）；DR 组的病程、血清尿酸（SUA）、尿素氮（BUN）均高于NDR 组，差异有统计学意义（P＜0.05）；两组的年龄、性别、体重指数（BMI）、收缩压（SBP）、舒张压（DBP）、糖化血红蛋白（HbA1c）、空腹血糖（FPG）、三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）及血肌酐（Scr）比较，差异无统计学意义（P＞0.05）；Logistic 回归模型分析，病程（β=0.116，OR=1.123，95%CI：1.087～1.160）、SUA（β=0.003，OR=1.003，95%CI=1.000～1.005）为DR 的独立危险因素（P＜0.05）。结论中老年2 型糖尿病患者DR 患病率随着病程显著增加，病程、SUN 是DR 的独立危险因素。

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	郭爽
	白冬志
	王杨

关键词 ： 2 型糖尿病, 糖尿病性视网膜病变, 病程, 尿酸

Abstract：Objective To investigate the influencing factors of diabetic retinopathy (DR) in middle-aged and elderly patients with type 2 diabetes mellitus.Methods A total of 460 middle-aged and elderly patients with type 2 diabetes mellitus who were admitted to Huludao Central Hospital from January 2018 to December 2019 were selected as the research subjects.They were subjected to history collection and physical examination, and fasting venous blood was collected to detect biochemical indicators.The fundus examination was performed by a professional ophthalmologist.According to the fundus conditions, they were divided into a normal fundus (NDR) group (295 cases) and a diabetic retinopathy (DR) group (165 cases).The prevalence of retinopathy in middle-aged and elderly patients with type 2 diabetes mellitus admitted to Huludao Central Hospital were summarized. Logistic regression model was used to analyze the correlation between DR and various influencing factors.Results The prevalence of DR was 35.9%, and the prevalence of DR was 18.1%, 31.6% and 53.8% in patients with disease course ＜5 years, 5-10 years and ＞10 years, respectively, the differences were statistically significant (P＜0.05).The course of disease, serum uric acid (SUA) and blood urea nitrogen (BUN) of the DR groups were higher than those of the NDR group, the differences were statistically significant (P＜0.05).There were no significant differences in age, gender, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), triglycerides(TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and serum creatinine (Scr)between the two groups. Logistic regression analysis showed that the course of disease (β=0.116, OR=1.123, 95%CI=1.087-1.160) and SUA (β=0.003, OR=1.003, 95%CI=1.000-1.005) were independent risk factors of DR (P＜0.05).Conclusion The prevalence of DR in middle-aged and elderly patients with type 2 diabetes mellitus significantly with the prolonged course of disease.Course of disease and SUA are independent risk factors for diabetic retinopathy.

Key words： Type 2 diabetes mellitus Diabetic retinopathy Course of disease Uric acid

引用本文:

郭爽 ;白冬志; 王杨. 中老年2型糖尿病患者视网膜病变的影响因素分析[J]. 中国当代医药, 2021, 28(10): 137-140.
GUO Shuang; BAI Dong-zhi; WANG Yang. Analysis of influencing factors of retinopathy in middle-aged and elderly patients with type 2 diabetes mellitus. 中国当代医药, 2021, 28(10): 137-140.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2021/V28/I10/137

[1]	彭紧紧，李青菊，田晨光，等.血清尿酸基线水平与2 型糖尿病视网膜病变进展的相关性[J].山东医药，2018，58（45）：41-44.
[2]	Alberti KG，Zimmet PZ.Definition，diagnosis and classification of diabetes mellitus and its complications.Provisional report of a WHO consultation[J].Diabet Med，1998，15（7）：539-553.
[3]	Wilkinson CP，Ferris FL，Klein RE，et al.Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales[J].Ophthalmology，2003，110（9）：1677-1682.
[4]	魏文文，杨秀芬，顾虹，等.北京德胜社区2 型糖尿病人群中糖尿病视网膜病变与糖尿病周围神经病变的相关性研究[J].中华眼科杂志，2017，53（7）：509-513.
[5]	Cui J，Ren JP，Chen DN，et al.Prevalence and associated factors of diabetic retino pathy in Beijing，China：a crosssectional study[J].BMJ open，2017，7（8）：e015473.
[6]	李会琳，郝少峰，裴鹏鹏.80 岁及以上糖尿病患者血脂与糖尿病视网膜病变相关性研究[J].中华老年医学杂志，2018，30（12）：1376-1378.
[7]	杨健，杨凤娟，苗晓，等.糖尿病性视网膜病变发生机制研究进展[J].中国老年学杂志，2017，37（18）：4680-4682.
[8]	姚晓楠，王良雨，彭丽俊，等.microRNAs 在糖尿病视网膜病变发病机制中的作用[J].国际眼科杂志，2019，19（9）：1507-1511.
[9]	佘新平，郑志.血清尿酸水平在2 型糖尿病患者视网膜病变发病中的预测作用[J].临床眼科杂志，2019，27（3）：221-225.
[10]	Liang CC，Lin PC，Lee MY，et al.Association of Serum Uric Acid Concentration with Diabetic Retinopathy and Albuminuria in Taiwanese Patients with Type 2 Diabetes Mellitus[J].Int J Mol Sci，2016，17（8）：1248.
[11]	Zhu DD，Wang YZ，Zou C，et al.The role of uric acid in the pathogenesis of diabetic retinopathy based on Notch pathway[J].Biochem Biophys Res Commun，2018，503（2）：921-929.
[12]	Braga TT，Forni MF，Correa-Costa M，et al.Soluble Uric Acid Activates the NLRP3 Inflammasome[J].Sci Rep，2017，7：39884.
[13]	王文颜，张学东.NLRP3 炎症小体在糖尿病视网膜病变中的作用[J].眼科新进展，2018，38（6）：587-591.
[17]	金佩瑶，彭金娟，邹海东，等.上海市新泾社区2 型糖尿病居民5年随访的前瞻性调查研究1.糖尿病视网膜病变和糖尿病黄斑水肿的发病率及危险因素[J].中华实验眼科杂志，2016，34（4）：363-367.
[18]	王芳，王敏，宋秋利，等.咸阳市秦都区2 型糖尿病患者糖尿病性视网膜病变的相关筛查[J].中国当代医药，2019，26（16）：213-216.
[14]	Liu QP，Li JM，Cheng R，et al.Nitrosative Stress Plays an Important Role in Wnt Pathway Activation in Diabetic Retinopathy[J].Antioxid Redox Signal，2013，18（10）：1141-1153.
[15]	Foresto-Neto O，Avila VF，Arias SCA，et al.NLRP3 inflammasome inhibition ameliorates tubulointerstitial injury in the remnant kidney model[J].Lab Invest，2018，98（6）：773-782.
[16]	Goharinia M，Zareei A，Rahimi M，et al.Can allopurinol improve retinopathy in diabetic rats Oxidative stress or uric acid；which one is the culprit?[J].Res Pharm Sci，2017，12（5）：401-408.
[19]	Cui J，Ren JP，Chen DN，et al.Prevalence and associated factors of diabetic retinopathy in Beijing，China：a crosssectional study[J].BMJ Open，2017，7（8）：e015473.