Abstract：Objective To study and analyze the effect of hepatitis B virus DNA content on pregnancy outcome.Methods From January 2017 to January 2019,270 parturients with HBV detected in the Department of Obstetrics,Maternal and Child Health Care Family Planning Service Center of Huizhou City were selected as the research objects.The DNA contents of 270 parturients were recorded.According to the level of HBV-DNA content,they were divided into three groups：group A(HBV-DNA＞1×106 copies/m,n=94),group B(5×102 copies/ml≤HBV-DNA≤1×106 copies/ml,n=86)and group C(HBV-DNA＜5×102 copies/ml,n=90).The complications of pregnancy hypertension,gestational diabetes,premature rupture of membranes and postpartum hemorrhage were compared among three groups,and the adverse impact of HBV-DNA content on the parturient were summarized.The incidence rates of premature delivery,neonatal asphyxia,low birth weight and stillbirth were compared among three groups,and the adverse impact of HBV-DNA content on the perinatal was summarized.Results The incidence rates of complications such as gestational hypertension,gestational diabetes,premature rupture of membranes and postpartum hemorrhage in group A were higher than those in group B and C,and the incidence rates of complications such as gestational hypertension,gestational diabetes,premature rupture of membranes and postpartum hemorrhage in group B were higher than those in group C,the differences were statistically significant(P＜0.05).The incidence rates of premature delivery,neonatal asphyxia and low birth weight in group A were higher than those in group B,the differences were statistically significant(P＜0.05).The incidence rates of premature delivery,neonatal asphyxia and low birth weight in group A were higher than those in group C,the differences were statistically significant(P＜0.05).There were no significant differences in the incidence rates of premature delivery,asphyxia and low birth weight between the two groups(P＞0.05).There were no significant differences in the incidence rates of stillbirth among the three groups(P＞0.05).Conclusion With the increase of hepatitis B virus DNA content,the incidence of complications such as pregnancy hypertension,gestational diabetes,premature rupture of membranes,postpartum hemorrhage and the incidence of premature delivery,neonatal asphyxia,low birth weight of newborn also increase,which will increase the adverse impact on pregnancy.
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