Abstract：Objective To observe the clinical effect of long-term home atomization inhaled Budesonide in the treatment of infants wheezing with positive asthma predictive index(API).Methods A total of 67 API positive patients visited the pediatric clinic at our center from January 2014 to January 2016 were selected and randomly divided into the observation group(n=34)and the control group(n=33).The observation group was treated with long-term home atomization inhaled Budesonide after acute asthma attack control,according to the effect of symptom control,the inhalation dose of Budesonide was adjusted from 1 mg/d to 0.25 mg/d.The course of treatment was from March to September.The control group was treated with high dose Budesonide suspension combined with Salbutamol Sulfate Solution and Ipratropium Bromide Solution at each wheezing attack,and the drug was discontinued after symptom control.Following up for 12 months,the number of wheezing relapses,duration of wheezing attacks and the use rate of systemic corticosteroids in severe wheezing attacks were observed and compared between the two groups.Results The recurrence times of wheezing in the observation group was(1.5±0.3)times,which was significantly less than(3.5±0.6)times in the control group,the difference was statistically significant(P＜0.05).The duration of wheezing attacks in the observation group was (3.7±0.8)days,which was shorter than (6.2±0.6)days in the control group,the difference was statistically significant(P＜0.05).The use rate of systemic corticosteroids in the observation group was 6.3%,which was significantly lower than that in the control group(15.1%),the difference was statistically significant(P＜0.05).After the course of treatment,there were no obvious adverse reactions in both groups.Conclusion Long-term home atomization inhaled Budesonide can effectively prevent the recurrence of asthma and alleviate the degree of asthma attack in API positive infants and young children,the curative effect is remarkable and the safety is good.
陈埃清; 刘麟; 管华. 长期家庭雾化布地奈德治疗哮喘预测指数阳性婴幼儿喘息的效果[J]. 中国当代医药, 2019, 26(8): 106-108.
CHEN Ai-qing; LIU Lin; GUAN Hua. Effect of the long-term home atomization inhaled Budesonide in the treatment of infants wheezing with positive asthma predictive index. 中国当代医药, 2019, 26(8): 106-108.
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