硫酸沙丁胺醇溶液联合布地奈德混悬液雾化吸入治疗小儿支气管哮喘合并肺炎的临床效果

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摘要目的探讨硫酸沙丁胺醇溶液联合布地奈德混悬液雾化吸入治疗小儿支气管哮喘合并肺炎的临床效果。方法选取2015年1月～2017年12月我院儿科收治的72例支气管哮喘合并肺炎患儿作为研究对象，将其随机分为观察组和对照组，每组各36例。观察组患儿采用硫酸沙丁胺醇溶液联合布地奈德混悬液雾化吸入治疗，对照组患儿采用布地奈德混悬液治疗。比较两组患儿的临床治疗效果、复发情况及治疗前后肺功能变化情况[1秒用力呼气容积（FEV1）、FEV1占比]。结果观察组患儿的治疗总有效率为94.4%，显著高于对照组的86.1%，差异有统计学意义（P＜0.05）。两组患儿治疗前的FEV1及FEV1占比比较，差异无统计学意义（P＞0.05）；两组患儿治疗后的FEV1及FEV1占比均显著高于治疗前，差异有统计学意义（P＜0.05）；观察组患儿治疗后的FEV1及FEV1占比均显著高于对照组，差异有统计学意义（P＜0.05）。观察组患儿的复发率为5.6%（2/36），显著低于对照组的22.2%（8/36），差异有统计学意义（P＜0.05）。结论硫酸沙丁胺醇溶液联合布地奈德混悬液雾化吸入治疗小儿支气管哮喘合并肺炎的临床效果确切，能显著改变临床症状，复发率低，值得临床推广应用。

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	虞致新
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关键词 ：硫酸沙丁胺醇溶液, 布地奈德混悬液, 小儿支气管哮喘, 肺炎

Abstract：Objective To investigate the clinical effect of Salbutamol Sulfate Solution combined with Budesonide Suspension aerosol inhalation in the treatment of children with bronchial asthma complicated with pneumonia.Methods Altogether 72 cases of children with bronchial asthma complicated with pneumonia who were treated in our hospital from January 2015 to December 2017 were selected as the research subjects,and they were randomly divided into the observation group and the control group,with 36 cases in each group.The observation group was treated with Salbutamol Sulfate Solution and Budesonide Suspension aerosol inhalation,while the control group was treated with Budesonide Suspension aerosol inhalation.The clinical treatment effect,recurrence and changes of lung function (1 second forced expiratory volume [FEV1],FEV1proportion)before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.4%,which was significantly higher than that in the control group(86.1%),and the difference was statistically significant(P＜0.05).There were no significant differences in the FEV1and proportion of FEV1between the two groups before treatment(P＞0.05).The FEV1and proportion of FEV1in the two groups after treatment were significantly higher than those before treatment,and the differences were statistically significant(P＜0.05).The FEV1and proportion of FEV1in the observation group after treatment were significantly higher than those in the control group,and the differences were statistically significant(P＜0.05).The recurrence rate of the observation group was 5.6%(2/36),which was significantly lower than that of the control group accounting for 22.2%(8/36),and the difference was statistically significant(P＜0.05).Conclusion The effect of Salbutamol Sulfate Solution combined with Budesonide Suspension aerosol inhalation is certain in the treatment of children with bronchial asthma complicated with pneumonia,and it can significantly change the clinical symptoms,with lower recurrence rate,which is worthy of clinical application.

Key words： Salbutamol Sulfate Solution Budesonide Suspension Children with bronchial asthma Pneumonia

基金资助:江西省萍乡市指导性科技计划项目（萍科鉴字[2014]第36号）

引用本文:

虞致新;谢小琴. 硫酸沙丁胺醇溶液联合布地奈德混悬液雾化吸入治疗小儿支气管哮喘合并肺炎的临床效果[J]. 中国当代医药, 2019, 26(2): 107-109.
YU Zhi-xin;XIE Xiao-qin. Clinical effect of Salbutamol Sulfate Solution combined with Budesonide Suspension aerosol inhalation in the treatment of children with bronchial asthma complicated with pneumonia. 中国当代医药, 2019, 26(2): 107-109.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2019/V26/I2/107

[1]	刘丹.吸入用布地奈德混悬液（普米克令舒）、吸入用硫酸沙丁胺醇溶液（万托林）联合甲强龙辅助治疗小儿毛细支气管炎的疗效及安全性[J].中外医疗，2015，6（19）：112.
[2]	潘云芳，胡晓红.β2-受体激动剂及糖皮质激素雾化吸入治疗儿科支气管哮喘合并肺炎的疗效观察[J].中国高等医学教育，2016，（4）：130-131.
[3]	杨瑛.小儿支气管哮喘与肺炎支原体感染的关系研究[J].河北医学，2011，17（9）：1151-1153.
[4]	庞蕾.β2-受体激动剂及糖皮质激素雾化吸入治疗小儿支气管哮喘合并肺炎的疗效[J].北方药学，2017，14（2）：98-99.
[5]	渚福棠.实用儿科学[M].8版.北京：人民卫生出版社，2015：1276-1277.
[6]	Pollock M，Sinha IP，Hartling L，et al.Inhaled short-acting bronchodilators for managing emergency childhood asthma：an overview of reviews[J].Allergy，2017，72（2）：183-200.
[7]	Chan R，Sousa AR，Mallett S，et al.Assessment of the efficacy and safety of fluticasone propionate and salmeterol delivered as acombination dry powder via a capsule based inhaler and a multi-dose inhaler in patients with asthma[J].Pulmo Pharmacol Ther，2016，41（1）：19-24.
[8]	朱云霞，李子健，张嫒嫒.沙丁胺醇长效药物联合其他抗炎药物治疗小儿支气管哮喘反复发作的临床治疗疗效评价[J].吉林医科大学附属医院，2014，12（33）：55-58.
[9]	荆安龙，郭梅，许峰.吸入用布地奈德混悬液（普米克令舒）、吸入用硫酸沙丁胺醇溶液（万托林）联合甲强龙辅助治疗小儿毛细支气管炎的临床研究[J].重庆医学，2015，44（25）：3534.
[10]	郑莉莉，李泽庚.吸入疗法在儿童支气管哮喘治疗中的应用[J].中医药临床杂志，2016，28（2）：151.
[11]	Kanniess F，Diamant Z，Lomax M.Effects of low versus highdosefluticasone propionate/formoterol fumarate combination therapy on AMP challenge in asthmatic patients：a doubleblind，randomised clinical trial[J].Pulm Pharmacol Ther，2016，37（1）：65-72.
[12]	肖雅琼，饶炎红.硫酸沙丁胺醇溶液联合布地奈德混悬液雾化吸入治疗小儿哮喘急性发作的疗效观察[J].中国医院用药评价与分析，2016，16（8）：1060-1061.
[13]	董灵芝，任志艳，董书领.布地奈德混悬液联合复方异丙托溴铵雾化吸入治疗小儿哮喘的疗效及护理[J].实用临床医药杂志，2015，19（8）：97-100.
[14]	张智敏.沙丁胺醇联合布地奈德雾化吸入治疗小儿支气管哮喘合并肺部感染的效果观察[J].右江民族医学院学报，2015，37（3）：439.
[15]	曾广文.硫酸沙丁胺醇溶液联合布地奈德气雾剂雾化吸入治疗小儿哮喘的疗效[J].实用临床医学，2016，17（8）：56-57.
[16]	陈辉，赖连娣，邓宏伟.布地奈德福莫特罗联合噻托溴铵治疗慢性阻塞性肺疾病急性加重期的临床观察[J].现代医院，2017，17（2）：233-235.
[17]	王志华.维生素D辅助治疗在儿童不同严重程度支气管哮喘患儿中的应用效果[J].中国医药导报，2018，15（3）：85-88.